Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug–Drug Interactions and Tolerability

Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinic...

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Vydáno v:	CNS drugs Ročník 35; číslo 6; s. 609 - 618
Hlavní autoři:	Roberti, Roberta, De Caro, Carmen, Iannone, Luigi Francesco, Zaccara, Gaetano, Lattanzi, Simona, Russo, Emilio
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cham Springer International Publishing 01.06.2021 Springer Nature B.V
Témata:	Adult Adverse events Allosteric properties Animals Anticonvulsants - administration & dosage Anticonvulsants - adverse effects Anticonvulsants - pharmacokinetics Benzodiazepines Binding sites Bioavailability Biological Availability Carbamates - administration & dosage Carbamates - adverse effects Carbamates - pharmacokinetics Carbamazepine Central nervous system Chlorophenols - administration & dosage Chlorophenols - adverse effects Chlorophenols - pharmacokinetics Clinical trials Convulsions & seizures Cytochrome P450 Dosage Dose-Response Relationship, Drug Drug dosages Drug Interactions Epilepsies, Partial - drug therapy Epilepsy Gait Humans Lamotrigine Medicine Medicine & Public Health Neurology Neurosciences Patients Pharmacodynamics Pharmacokinetics Pharmacology Pharmacotherapy Phenytoin Placebos Plasma levels Psychiatry Psychopharmacology Randomized Controlled Trials as Topic Review Article Seizures Sodium Sodium channels (voltage-gated) Tetrazoles - administration & dosage Tetrazoles - adverse effects Tetrazoles - pharmacokinetics Titration γ-Aminobutyric acid A receptors
ISSN:	1172-7047, 1179-1934, 1179-1934
On-line přístup:	Získat plný text
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