Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug–Drug Interactions and Tolerability
Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinic...
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| Published in: | CNS drugs Vol. 35; no. 6; pp. 609 - 618 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Springer International Publishing
01.06.2021
Springer Nature B.V |
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| ISSN: | 1172-7047, 1179-1934, 1179-1934 |
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| Abstract | Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinical response. Although the high rate of seizure freedom observed in randomized, placebo-controlled clinical trials has resulted in exciting expectations, further clinical studies are needed to better define its clinical profile. Cenobamate is characterized by a peculiar pharmacology regarding both pharmacodynamics and pharmacokinetics. The mechanism of action has only partly been described, with the drug acting on voltage-gated sodium channels through a pronounced action on persistent rather than transient currents. Cenobamate also acts as a positive allosteric modulator of GABA
A
receptors independently from the benzodiazepine binding site. The bioavailability of cenobamate is not influenced by other drugs, except phenytoin; it can inhibit cytochrome P450 (CYP) 2C19 and induce CYP3A4 and 2B6, and hence can potentially interact with many drugs (e.g. dose adjustments may be required for lamotrigine, carbamazepine and clobazam). The pharmacokinetics of cenobamate are not linear and dosage increases imply a disproportional increase in plasma levels, particularly at doses higher than 300 mg. The most common and dose-related adverse effects associated with cenobamate include central nervous system-related symptoms, mainly somnolence, dizziness, diplopia, and disturbances in gait and coordination. A somewhat higher incidence of adverse events has been observed in patients concomitantly treated with sodium channel blockers. The most relevant safety issues are currently represented by the risk of severe skin reactions (apparently avoidable by a slow titration) and QT shortening (the drug is contraindicated in patients with familial short QT syndrome or taking QT-shortening drugs). Overall, cenobamate is a promising ASM with an intriguing and not fully understood mechanism of action; pharmacokinetic issues need to be considered in clinical practice. |
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| AbstractList | Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinical response. Although the high rate of seizure freedom observed in randomized, placebo-controlled clinical trials has resulted in exciting expectations, further clinical studies are needed to better define its clinical profile. Cenobamate is characterized by a peculiar pharmacology regarding both pharmacodynamics and pharmacokinetics. The mechanism of action has only partly been described, with the drug acting on voltage-gated sodium channels through a pronounced action on persistent rather than transient currents. Cenobamate also acts as a positive allosteric modulator of GABA
receptors independently from the benzodiazepine binding site. The bioavailability of cenobamate is not influenced by other drugs, except phenytoin; it can inhibit cytochrome P450 (CYP) 2C19 and induce CYP3A4 and 2B6, and hence can potentially interact with many drugs (e.g. dose adjustments may be required for lamotrigine, carbamazepine and clobazam). The pharmacokinetics of cenobamate are not linear and dosage increases imply a disproportional increase in plasma levels, particularly at doses higher than 300 mg. The most common and dose-related adverse effects associated with cenobamate include central nervous system-related symptoms, mainly somnolence, dizziness, diplopia, and disturbances in gait and coordination. A somewhat higher incidence of adverse events has been observed in patients concomitantly treated with sodium channel blockers. The most relevant safety issues are currently represented by the risk of severe skin reactions (apparently avoidable by a slow titration) and QT shortening (the drug is contraindicated in patients with familial short QT syndrome or taking QT-shortening drugs). Overall, cenobamate is a promising ASM with an intriguing and not fully understood mechanism of action; pharmacokinetic issues need to be considered in clinical practice. Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinical response. Although the high rate of seizure freedom observed in randomized, placebo-controlled clinical trials has resulted in exciting expectations, further clinical studies are needed to better define its clinical profile. Cenobamate is characterized by a peculiar pharmacology regarding both pharmacodynamics and pharmacokinetics. The mechanism of action has only partly been described, with the drug acting on voltage-gated sodium channels through a pronounced action on persistent rather than transient currents. Cenobamate also acts as a positive allosteric modulator of GABAA receptors independently from the benzodiazepine binding site. The bioavailability of cenobamate is not influenced by other drugs, except phenytoin; it can inhibit cytochrome P450 (CYP) 2C19 and induce CYP3A4 and 2B6, and hence can potentially interact with many drugs (e.g. dose adjustments may be required for lamotrigine, carbamazepine and clobazam). The pharmacokinetics of cenobamate are not linear and dosage increases imply a disproportional increase in plasma levels, particularly at doses higher than 300 mg. The most common and dose-related adverse effects associated with cenobamate include central nervous system-related symptoms, mainly somnolence, dizziness, diplopia, and disturbances in gait and coordination. A somewhat higher incidence of adverse events has been observed in patients concomitantly treated with sodium channel blockers. The most relevant safety issues are currently represented by the risk of severe skin reactions (apparently avoidable by a slow titration) and QT shortening (the drug is contraindicated in patients with familial short QT syndrome or taking QT-shortening drugs). Overall, cenobamate is a promising ASM with an intriguing and not fully understood mechanism of action; pharmacokinetic issues need to be considered in clinical practice. Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinical response. Although the high rate of seizure freedom observed in randomized, placebo-controlled clinical trials has resulted in exciting expectations, further clinical studies are needed to better define its clinical profile. Cenobamate is characterized by a peculiar pharmacology regarding both pharmacodynamics and pharmacokinetics. The mechanism of action has only partly been described, with the drug acting on voltage-gated sodium channels through a pronounced action on persistent rather than transient currents. Cenobamate also acts as a positive allosteric modulator of GABA A receptors independently from the benzodiazepine binding site. The bioavailability of cenobamate is not influenced by other drugs, except phenytoin; it can inhibit cytochrome P450 (CYP) 2C19 and induce CYP3A4 and 2B6, and hence can potentially interact with many drugs (e.g. dose adjustments may be required for lamotrigine, carbamazepine and clobazam). The pharmacokinetics of cenobamate are not linear and dosage increases imply a disproportional increase in plasma levels, particularly at doses higher than 300 mg. The most common and dose-related adverse effects associated with cenobamate include central nervous system-related symptoms, mainly somnolence, dizziness, diplopia, and disturbances in gait and coordination. A somewhat higher incidence of adverse events has been observed in patients concomitantly treated with sodium channel blockers. The most relevant safety issues are currently represented by the risk of severe skin reactions (apparently avoidable by a slow titration) and QT shortening (the drug is contraindicated in patients with familial short QT syndrome or taking QT-shortening drugs). Overall, cenobamate is a promising ASM with an intriguing and not fully understood mechanism of action; pharmacokinetic issues need to be considered in clinical practice. Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinical response. Although the high rate of seizure freedom observed in randomized, placebo-controlled clinical trials has resulted in exciting expectations, further clinical studies are needed to better define its clinical profile. Cenobamate is characterized by a peculiar pharmacology regarding both pharmacodynamics and pharmacokinetics. The mechanism of action has only partly been described, with the drug acting on voltage-gated sodium channels through a pronounced action on persistent rather than transient currents. Cenobamate also acts as a positive allosteric modulator of GABAA receptors independently from the benzodiazepine binding site. The bioavailability of cenobamate is not influenced by other drugs, except phenytoin; it can inhibit cytochrome P450 (CYP) 2C19 and induce CYP3A4 and 2B6, and hence can potentially interact with many drugs (e.g. dose adjustments may be required for lamotrigine, carbamazepine and clobazam). The pharmacokinetics of cenobamate are not linear and dosage increases imply a disproportional increase in plasma levels, particularly at doses higher than 300 mg. The most common and dose-related adverse effects associated with cenobamate include central nervous system-related symptoms, mainly somnolence, dizziness, diplopia, and disturbances in gait and coordination. A somewhat higher incidence of adverse events has been observed in patients concomitantly treated with sodium channel blockers. The most relevant safety issues are currently represented by the risk of severe skin reactions (apparently avoidable by a slow titration) and QT shortening (the drug is contraindicated in patients with familial short QT syndrome or taking QT-shortening drugs). Overall, cenobamate is a promising ASM with an intriguing and not fully understood mechanism of action; pharmacokinetic issues need to be considered in clinical practice.Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinical response. Although the high rate of seizure freedom observed in randomized, placebo-controlled clinical trials has resulted in exciting expectations, further clinical studies are needed to better define its clinical profile. Cenobamate is characterized by a peculiar pharmacology regarding both pharmacodynamics and pharmacokinetics. The mechanism of action has only partly been described, with the drug acting on voltage-gated sodium channels through a pronounced action on persistent rather than transient currents. Cenobamate also acts as a positive allosteric modulator of GABAA receptors independently from the benzodiazepine binding site. The bioavailability of cenobamate is not influenced by other drugs, except phenytoin; it can inhibit cytochrome P450 (CYP) 2C19 and induce CYP3A4 and 2B6, and hence can potentially interact with many drugs (e.g. dose adjustments may be required for lamotrigine, carbamazepine and clobazam). The pharmacokinetics of cenobamate are not linear and dosage increases imply a disproportional increase in plasma levels, particularly at doses higher than 300 mg. The most common and dose-related adverse effects associated with cenobamate include central nervous system-related symptoms, mainly somnolence, dizziness, diplopia, and disturbances in gait and coordination. A somewhat higher incidence of adverse events has been observed in patients concomitantly treated with sodium channel blockers. The most relevant safety issues are currently represented by the risk of severe skin reactions (apparently avoidable by a slow titration) and QT shortening (the drug is contraindicated in patients with familial short QT syndrome or taking QT-shortening drugs). Overall, cenobamate is a promising ASM with an intriguing and not fully understood mechanism of action; pharmacokinetic issues need to be considered in clinical practice. |
| Author | Russo, Emilio Zaccara, Gaetano Iannone, Luigi Francesco Roberti, Roberta De Caro, Carmen Lattanzi, Simona |
| Author_xml | – sequence: 1 givenname: Roberta surname: Roberti fullname: Roberti, Roberta organization: Science of Health Department, University Magna Grecia of Catanzaro – sequence: 2 givenname: Carmen surname: De Caro fullname: De Caro, Carmen organization: Science of Health Department, University Magna Grecia of Catanzaro – sequence: 3 givenname: Luigi Francesco surname: Iannone fullname: Iannone, Luigi Francesco organization: Science of Health Department, University Magna Grecia of Catanzaro – sequence: 4 givenname: Gaetano surname: Zaccara fullname: Zaccara, Gaetano organization: Regional Health Agency of Tuscany – sequence: 5 givenname: Simona surname: Lattanzi fullname: Lattanzi, Simona organization: Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University – sequence: 6 givenname: Emilio orcidid: 0000-0002-1279-8123 surname: Russo fullname: Russo, Emilio email: erusso@unicz.it organization: Science of Health Department, University Magna Grecia of Catanzaro |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33993416$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neuropharm.2017.04.020 10.1016/j.eplepsyres.2010.09.001 10.1016/j.ejphar.2019.05.007 10.1016/j.ejphar.2020.173117 10.1016/j.seizure.2013.04.015 10.1002/ana.24295 10.1159/000503831 10.1016/S1474-4422(19)30399-0 10.1016/j.yebeh.2020.106939 10.1212/WNL.0000000000009530 10.1177/1060028020941113 10.1002/cpdd.769 10.1016/j.neuropharm.2020.107966 10.1111/epi.16525 10.1111/epi.12289 10.1016/j.tips.2016.04.003 10.1007/s40263-020-00759-9 10.1001/jamaneurol.2017.3949 10.1111/epi.12294 10.1684/epd.2014.0714 10.1111/j.1535-7597.2004.42010.x 10.1111/epi.16718 10.1016/S2468-2667(20)30190-0 10.1111/epi.12657 10.1002/acn3.408 10.1007/s13318-020-00615-7 10.1124/mol.107.039867 10.1212/WNL.92.15_supplement.P1.5-034 10.1002/cpt.1344 |
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| References | Broomall, Natale, Grimason, Goldstein, Smith, Chang (CR20) 2014; 76 Sills, Rogawski (CR12) 2020; 168 Beghi (CR1) 2020; 54 Errington, Stöhr, Heers, Lees (CR15) 2008; 73 Vernillet, Kamin (CR28) 2018; 103 Vernillet, Greene, Kamin (CR24) 2020; 9 Nakamura, Cho, Shin, Jang (CR10) 2019; 855 Lattanzi, Trinka, Zaccara, Striano, Del Giovane, Silvestrini (CR7) 2020; 34 Zaccara, Perucca (CR27) 2014; 16 Sharma, Nakamura, Neupane, Jeon, Shin, Melnick (CR11) 2020; 879 CR34 CR32 CR31 CR30 George (CR13) 2004; 4 Deuschl, Beghi, Fazekas, Varga, Christoforidi, Sipido (CR2) 2020; 5 Vernillet, Greene, Kim, Melnick, Glenn (CR25) 2020; 45 Lévesque, Herrington, Leclerc, Rogawski, Avoli (CR18) 2017; 121 Vaitkevicius, Husain, Rosenthal, Rosand, Bobb, Reddy (CR21) 2017; 4 Bialer, Johannessen, Levy, Perucca, Tomson, White (CR9) 2010; 92 Rogawski, Loya, Reddy, Zolkowska, Lossin (CR19) 2013; 54 French, White, Klitgaard, Holmes, Privitera, Cole (CR4) 2013; 54 Verrotti, Lattanzi, Brigo, Zaccara (CR22) 2020; 104 Reddy, Estes (CR17) 2016; 37 Greene, Orlinski, Streicher, Vernillet (CR26) 2019; 92 Anderson, Thompson, Hawkins, Nath, Petersohn, Rajamani (CR14) 2014; 55 Guignet, Campbell, White (CR8) 2020; 61 Greenfield (CR16) 2013; 22 Krauss, Klein, Brandt, Lee, Milanov, Milovanovic (CR6) 2020; 19 CR23 Chung, French, Kowalski, Krauss, Lee, Maciejowski (CR5) 2020; 94 Sperling, Klein, Aboumatar, Gelfand, Halford, Krauss (CR29) 2020; 61 Chen, Brodie, Liew, Kwan (CR3) 2018; 75 Buckley, Waters, DeMaagd (CR33) 2021; 55 LJ Greenfield (819_CR16) 2013; 22 DS Reddy (819_CR17) 2016; 37 AL George (819_CR13) 2004; 4 G Zaccara (819_CR27) 2014; 16 A Verrotti (819_CR22) 2020; 104 MA Rogawski (819_CR19) 2013; 54 E Broomall (819_CR20) 2014; 76 S Greene (819_CR26) 2019; 92 CT Buckley (819_CR33) 2021; 55 JA French (819_CR4) 2013; 54 Z Chen (819_CR3) 2018; 75 LL Anderson (819_CR14) 2014; 55 E Beghi (819_CR1) 2020; 54 M Nakamura (819_CR10) 2019; 855 AC Errington (819_CR15) 2008; 73 M Guignet (819_CR8) 2020; 61 L Vernillet (819_CR25) 2020; 45 S Lattanzi (819_CR7) 2020; 34 819_CR23 GL Krauss (819_CR6) 2020; 19 L Vernillet (819_CR28) 2018; 103 H Vaitkevicius (819_CR21) 2017; 4 L Vernillet (819_CR24) 2020; 9 R Sharma (819_CR11) 2020; 879 G Deuschl (819_CR2) 2020; 5 GJ Sills (819_CR12) 2020; 168 M Bialer (819_CR9) 2010; 92 MR Sperling (819_CR29) 2020; 61 M Lévesque (819_CR18) 2017; 121 SS Chung (819_CR5) 2020; 94 819_CR30 819_CR32 819_CR31 819_CR34 |
| References_xml | – volume: 121 start-page: 12 year: 2017 end-page: 19 ident: CR18 article-title: Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2017.04.020 – volume: 92 start-page: 89 year: 2010 end-page: 124 ident: CR9 article-title: Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X) publication-title: Epilepsy Res doi: 10.1016/j.eplepsyres.2010.09.001 – volume: 855 start-page: 175 year: 2019 end-page: 182 ident: CR10 article-title: Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2019.05.007 – volume: 92 start-page: P1.5-034 year: 2019 ident: CR26 article-title: The pharmacokinetics of cenobamate in special populations (P1.5–034) publication-title: Neurology – volume: 879 start-page: 173117 year: 2020 ident: CR11 article-title: Positive allosteric modulation of GABAA receptors by a novel antiepileptic drug cenobamate publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2020.173117 – volume: 22 start-page: 589 year: 2013 end-page: 600 ident: CR16 article-title: Molecular mechanisms of antiseizure drug activity at GABAA receptors publication-title: Seizure doi: 10.1016/j.seizure.2013.04.015 – volume: 76 start-page: 911 year: 2014 end-page: 915 ident: CR20 article-title: Pediatric super-refractory status epilepticus treated with allopregnanolone publication-title: Ann Neurol. doi: 10.1002/ana.24295 – volume: 54 start-page: 185 year: 2020 end-page: 191 ident: CR1 article-title: The epidemiology of epilepsy publication-title: Neuroepidemiology doi: 10.1159/000503831 – volume: 19 start-page: 38 year: 2020 end-page: 48 ident: CR6 article-title: Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial publication-title: Lancet Neurol doi: 10.1016/S1474-4422(19)30399-0 – ident: CR30 – volume: 104 start-page: 106939 issue: Pt A year: 2020 ident: CR22 article-title: Pharmacodynamic interactions of antiepileptic drugs: From bench to clinical practice publication-title: Epilepsy Behav doi: 10.1016/j.yebeh.2020.106939 – volume: 94 start-page: e2311 year: 2020 end-page: e2322 ident: CR5 article-title: Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures publication-title: Neurology doi: 10.1212/WNL.0000000000009530 – volume: 55 start-page: 318 issue: 3 year: 2021 end-page: 329 ident: CR33 article-title: Cenobamate: a new adjunctive agent for drug-resistant focal onset epilepsy publication-title: Ann Pharmacother. doi: 10.1177/1060028020941113 – ident: CR23 – volume: 9 start-page: 428 year: 2020 end-page: 443 ident: CR24 article-title: Pharmacokinetics of cenobamate: results from single and multiple oral ascending-dose studies in healthy subjects publication-title: Clin Pharmacol Drug Dev. doi: 10.1002/cpdd.769 – volume: 168 start-page: 107966 year: 2020 ident: CR12 article-title: Mechanisms of action of currently used antiseizure drugs publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2020.107966 – volume: 61 start-page: 1099 year: 2020 end-page: 1108 ident: CR29 article-title: Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study publication-title: Epilepsia doi: 10.1111/epi.16525 – volume: 54 start-page: 93 year: 2013 end-page: 98 ident: CR19 article-title: Neuroactive steroids for the treatment of status epilepticus publication-title: Epilepsia doi: 10.1111/epi.12289 – volume: 37 start-page: 543 year: 2016 end-page: 561 ident: CR17 article-title: Clinical potential of neurosteroids for CNS disorders publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2016.04.003 – volume: 34 start-page: 1105 year: 2020 end-page: 1120 ident: CR7 article-title: Adjunctive cenobamate for focal-onset seizures in adults: a systematic review and meta-analysis publication-title: CNS Drugs doi: 10.1007/s40263-020-00759-9 – volume: 75 start-page: 279 year: 2018 end-page: 286 ident: CR3 article-title: Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs a 30-year longitudinal cohort study publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2017.3949 – volume: 54 start-page: 3 year: 2013 end-page: 12 ident: CR4 article-title: Development of new treatment approaches for epilepsy: unmet needs and opportunities publication-title: Epilepsia doi: 10.1111/epi.12294 – ident: CR31 – volume: 16 start-page: 409 year: 2014 end-page: 431 ident: CR27 article-title: Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs publication-title: Epileptic Disord. doi: 10.1684/epd.2014.0714 – volume: 103 start-page: S91 year: 2018 ident: CR28 article-title: Drug–drug interactions between cenobamate and other antiepileptic drugs: results from phase I studies with carbamazepine, phenobarbital, phenytoin, and divalproex sodium publication-title: Clin Pharmacol Ther. – ident: CR32 – ident: CR34 – volume: 4 start-page: 65 year: 2004 end-page: 70 ident: CR13 article-title: Inherited channelopathies associated with epilepsy publication-title: Epilepsy Curr doi: 10.1111/j.1535-7597.2004.42010.x – volume: 61 start-page: 2329 year: 2020 end-page: 2339 ident: CR8 article-title: Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action? publication-title: Epilepsia doi: 10.1111/epi.16718 – volume: 5 start-page: e551 year: 2020 end-page: e567 ident: CR2 article-title: The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017 publication-title: Lancet Public Health doi: 10.1016/S2468-2667(20)30190-0 – volume: 55 start-page: 1274 year: 2014 end-page: 1283 ident: CR14 article-title: Antiepileptic activity of preferential inhibitors of persistent sodium current publication-title: Epilepsia doi: 10.1111/epi.12657 – volume: 4 start-page: 411 year: 2017 end-page: 414 ident: CR21 article-title: First-in-man allopregnanolone use in super-refractory status epilepticus publication-title: Ann Clin Transl Neurol. doi: 10.1002/acn3.408 – volume: 45 start-page: 513 year: 2020 end-page: 522 ident: CR25 article-title: Mass balance, metabolism, and excretion of cenobamate, a new antiepileptic drug, after a single oral administration in healthy male subjects publication-title: Eur J Drug Metab Pharmacokinet. doi: 10.1007/s13318-020-00615-7 – volume: 73 start-page: 157 year: 2008 end-page: 169 ident: CR15 article-title: The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels publication-title: Mol Pharmacol. doi: 10.1124/mol.107.039867 – volume: 75 start-page: 279 year: 2018 ident: 819_CR3 publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2017.3949 – ident: 819_CR32 – volume: 37 start-page: 543 year: 2016 ident: 819_CR17 publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2016.04.003 – volume: 92 start-page: P1.5-034 year: 2019 ident: 819_CR26 publication-title: Neurology doi: 10.1212/WNL.92.15_supplement.P1.5-034 – volume: 168 start-page: 107966 year: 2020 ident: 819_CR12 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2020.107966 – volume: 855 start-page: 175 year: 2019 ident: 819_CR10 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2019.05.007 – volume: 4 start-page: 411 year: 2017 ident: 819_CR21 publication-title: Ann Clin Transl Neurol. doi: 10.1002/acn3.408 – volume: 73 start-page: 157 year: 2008 ident: 819_CR15 publication-title: Mol Pharmacol. doi: 10.1124/mol.107.039867 – volume: 104 start-page: 106939 issue: Pt A year: 2020 ident: 819_CR22 publication-title: Epilepsy Behav doi: 10.1016/j.yebeh.2020.106939 – volume: 54 start-page: 3 year: 2013 ident: 819_CR4 publication-title: Epilepsia doi: 10.1111/epi.12294 – volume: 19 start-page: 38 year: 2020 ident: 819_CR6 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(19)30399-0 – volume: 22 start-page: 589 year: 2013 ident: 819_CR16 publication-title: Seizure doi: 10.1016/j.seizure.2013.04.015 – volume: 55 start-page: 1274 year: 2014 ident: 819_CR14 publication-title: Epilepsia doi: 10.1111/epi.12657 – volume: 54 start-page: 93 year: 2013 ident: 819_CR19 publication-title: Epilepsia doi: 10.1111/epi.12289 – volume: 9 start-page: 428 year: 2020 ident: 819_CR24 publication-title: Clin Pharmacol Drug Dev. doi: 10.1002/cpdd.769 – volume: 55 start-page: 318 issue: 3 year: 2021 ident: 819_CR33 publication-title: Ann Pharmacother. doi: 10.1177/1060028020941113 – ident: 819_CR31 – volume: 16 start-page: 409 year: 2014 ident: 819_CR27 publication-title: Epileptic Disord. doi: 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10.1016/j.ejphar.2020.173117 – volume: 76 start-page: 911 year: 2014 ident: 819_CR20 publication-title: Ann Neurol. doi: 10.1002/ana.24295 – volume: 45 start-page: 513 year: 2020 ident: 819_CR25 publication-title: Eur J Drug Metab Pharmacokinet. doi: 10.1007/s13318-020-00615-7 – ident: 819_CR34 – volume: 5 start-page: e551 year: 2020 ident: 819_CR2 publication-title: Lancet Public Health doi: 10.1016/S2468-2667(20)30190-0 – volume: 34 start-page: 1105 year: 2020 ident: 819_CR7 publication-title: CNS Drugs doi: 10.1007/s40263-020-00759-9 – volume: 121 start-page: 12 year: 2017 ident: 819_CR18 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2017.04.020 |
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