Compression-dependent microtubule reinforcement enables cells to navigate confined environments

Cells migrating through complex three-dimensional environments experience considerable physical challenges, including tensile stress and compression. To move, cells need to resist these forces while also squeezing the large nucleus through confined spaces. This requires highly coordinated cortical c...

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Bibliographic Details
Published in:	Nature cell biology Vol. 26; no. 9; pp. 1520 - 1534
Main Authors:	Ju, Robert J., Falconer, Alistair D., Schmidt, Christanny J., Enriquez Martinez, Marco A., Dean, Kevin M., Fiolka, Reto P., Sester, David P., Nobis, Max, Timpson, Paul, Lomakin, Alexis J., Danuser, Gaudenz, White, Melanie D., Haass, Nikolas K., Oelz, Dietmar B., Stehbens, Samantha J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.09.2024 Nature Publishing Group
Subjects:	631/80/128/1653 631/80/84/2336 Actomyosin Actomyosin - metabolism Animals Biology Biomedical and Life Sciences Cancer Research Cell activation Cell Biology Cell migration Cell Movement Cell Nucleus - metabolism Cells Cellular structure Compression Confined spaces Contractility Developmental Biology Humans Life Sciences Localization Mechanotransduction, Cellular Mice Microfilament Proteins Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules Microtubules - metabolism Nuclei (cytology) Polymers Proteins Signal transduction Stem Cells Stress, Mechanical Tensile stress Three dimensional motion
ISSN:	1465-7392, 1476-4679, 1476-4679
Online Access:	Get full text
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