The thioredoxin system and cancer therapy: a review

Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of the Trx system that is involved in redox regulation and antioxidant defense. In recent years, several researchers have provided information about the roles of the Trx system in cancer development and progression. These rep...

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Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 84; no. 5; pp. 925 - 935
Main Authors:	Mohammadi, Fariba, Soltani, Arash, Ghahremanloo, Atefeh, Javid, Hossein, Hashemy, Seyed Isaac
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2019 Springer Nature B.V
Subjects:	Animals Antineoplastic Agents - pharmacology Antineoplastic drugs Antioxidants Antioxidants - metabolism Antitumor activity Antitumor agents Apoptosis Apoptosis - drug effects Cancer Cancer Research Cancer therapies Chemotherapy Drug resistance Humans Medicine Medicine & Public Health NADP NADP - metabolism Neoplasms - drug therapy Neoplasms - pathology Oncology Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Reductase Review Article Thioredoxin Thioredoxin-Disulfide Reductase - metabolism Thioredoxins - metabolism Tumor cells Tumorigenesis Oxidative stress Thioredoxin Thioredoxin reductase Cancer therapy Cancer
ISSN:	0344-5704, 1432-0843, 1432-0843
Online Access:	Get full text
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