The thioredoxin system and cancer therapy: a review

Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of the Trx system that is involved in redox regulation and antioxidant defense. In recent years, several researchers have provided information about the roles of the Trx system in cancer development and progression. These rep...

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Published in:Cancer chemotherapy and pharmacology Vol. 84; no. 5; pp. 925 - 935
Main Authors: Mohammadi, Fariba, Soltani, Arash, Ghahremanloo, Atefeh, Javid, Hossein, Hashemy, Seyed Isaac
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2019
Springer Nature B.V
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antineoplastic drugs
Antioxidants
Antioxidants - metabolism
Antitumor activity
Antitumor agents
Apoptosis
Apoptosis - drug effects
Cancer
Cancer Research
Cancer therapies
Chemotherapy
Drug resistance
Humans
Medicine
Medicine & Public Health
NADP
NADP - metabolism
Neoplasms - drug therapy
Neoplasms - pathology
Oncology
Oxidative stress
Oxidative Stress - drug effects
Pharmacology/Toxicology
Reductase
Review Article
Thioredoxin
Thioredoxin-Disulfide Reductase - metabolism
Thioredoxins - metabolism
Tumor cells
Tumorigenesis
Oxidative stress
Thioredoxin
Thioredoxin reductase
Cancer therapy
Cancer
ISSN:0344-5704, 1432-0843, 1432-0843
Online Access:Get full text
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Summary:Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of the Trx system that is involved in redox regulation and antioxidant defense. In recent years, several researchers have provided information about the roles of the Trx system in cancer development and progression. These reports indicated that many tumor cells express high levels of Trx and TrxR, which can be responsible for drug resistance in tumorigenesis. Inhibition of the Trx system may thus contribute to cancer therapy and improving chemotherapeutic agents. There are now a number of effective natural and synthetic inhibitors with chemotherapy applications possessing antitumor activity ranging from oxidative stress induction to apoptosis. In this article, we first described the features and functions of the Trx system and then reviewed briefly its correlations with cancer. Finally, we summarized the present knowledge about the Trx/TrxR inhibitors as anticancer drugs.
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ISSN:0344-5704
1432-0843
1432-0843
DOI:10.1007/s00280-019-03912-4