A clinically feasible 7-Tesla protocol for the identification of cortical lesions in Multiple Sclerosis

Objectives The aim of this study was to evaluate the capability of sequences acquired on a 7-T MRI scanner, within times and anatomical coverage appropriate for clinical studies, to identify cortical lesions (CLs) in patients with Multiple Sclerosis (MS). Furthermore, we aimed to confirm the clinica...

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Veröffentlicht in:European radiology Jg. 30; H. 8; S. 4586 - 4594
Hauptverfasser: Cocozza, Sirio, Cosottini, Mirco, Signori, Alessio, Fleysher, Lazar, El Mendili, Mohamed Mounir, Lublin, Fred, Inglese, Matilde, Roccatagliata, Luca
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2020
Springer Nature B.V
Schlagworte:
Adult
Aged
Cerebral Cortex - pathology
Clinical Protocols
Cognitive ability
Correlation coefficient
Correlation coefficients
Diagnostic Radiology
Feasibility Studies
Female
Gray Matter - pathology
Humans
Image detection
Imaging
Imaging, Three-Dimensional - methods
Internal Medicine
Interventional Radiology
Lesions
Magnetic Resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis
Multiple Sclerosis - diagnosis
Neuroradiology
Radiology
Regression analysis
Regression models
Scanners
Substantia grisea
Ultrasound
Young Adult
Magnetic resonance imaging
Gray matter
Multiple sclerosis
ISSN:0938-7994, 1432-1084, 1432-1084
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Zusammenfassung:Objectives The aim of this study was to evaluate the capability of sequences acquired on a 7-T MRI scanner, within times and anatomical coverage appropriate for clinical studies, to identify cortical lesions (CLs) in patients with Multiple Sclerosis (MS). Furthermore, we aimed to confirm the clinical significance of CL, testing the correlations between gray matter (GM) lesions and clinical scores. Methods A 7-T MRI protocol included 3D-T1-weighted and T2*-weighted sequences. Images were evaluated independently by three readers of different experience, and the number of CLs was recorded. Between-rater concordance was assessed calculating the intraclass correlation coefficient (ICC). Lin’s concordance correlation coefficient was used to compare CL detection between sequences, while partial correlations and multivariable regression models were used to study the relationship between CL and clinical data. Results Forty MS patients (M/F, 17/23; 44.7 ± 12.6 years) were enrolled in this study, and CLs were identified in 35/40 subjects (87.5%). CL detection rate on 3D-T1-weighted images was significantly correlated with the detection rate on T2*-weighted images ( r  = 0.99; p  < 0.001), with high concordance between readers (ICC ≥ 0.995). CLs were significantly correlated with both motor and cognitive scores (all with p  ≤ 0.04). Conclusions CL can be identified over the whole brain at 7-T in MS using a 3D-T1-weighted volume, acquired in a clinically feasible time and with comparable performance to that achievable using the T2*-weighted sequence. Based on the central role of CL in the development of clinical disability, we suggest that 3D-T1-weighted volume may play a role in the evaluation of CL in MS undergoing MRI on ultra-high-field scanners. Key Points • Cortical lesions can be identified in a clinically feasible time with a 7-T protocol, which includes a 3D-T1-weighted volume. • Cortical lesions correlated significantly with both motor and cognitive disability in MS patients. • Given their correlation with clinical disability, evaluation of a cortical lesion on a 7-T clinical protocol could help in the management of MS patients.
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ISSN:0938-7994
1432-1084
1432-1084
DOI:10.1007/s00330-020-06803-y