Adipose-derived mesenchymal stem cell exosomes: a novel pathway for tissues repair

The well-characterized curative effect of transplanted mesenchymal stem cells has been mainly attributed to their homing and subsequent differentiation for the repair and regeneration of damaged tissue. Adipose-derived mesenchymal stem cells (ADMSCs) are not only multipotent and plastic, but also ab...

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Vydáno v:Cell and tissue banking Ročník 20; číslo 2; s. 153 - 161
Hlavní autoři: Fang, Yuan, Zhang, Yufang, Zhou, Jianda, Cao, Ke
Médium: Journal Article
Jazyk:angličtina
Vydáno: Dordrecht Springer Netherlands 01.06.2019
Springer Nature B.V
Témata:
Adipose Tissue - cytology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Differentiation
Drug Carriers
Exosomes
Exosomes - physiology
Guided Tissue Regeneration - methods
Humans
Life Sciences
Membrane vesicles
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells - physiology
Mesenchyme
Mini Review
Neuroprotection
Regeneration
Stem cells
Therapeutic applications
Transplant Surgery
Exosomes
Adipose-derived mesenchymal stem cell
Tissues repair mechanism
ISSN:1389-9333, 1573-6814, 1573-6814
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Shrnutí:The well-characterized curative effect of transplanted mesenchymal stem cells has been mainly attributed to their homing and subsequent differentiation for the repair and regeneration of damaged tissue. Adipose-derived mesenchymal stem cells (ADMSCs) are not only multipotent and plastic, but also abundant as they can be easily harvested with minimally invasive surgical techniques. This makes ADMSCs conducive for clinical applications. Recently, the secretory function of ADMSCs has been regarded as the primary mediator of MSC-based therapy. Exosomes are one kind of small cell extracellular membrane vesicles, which are primarily used to deliver cell-specific proteins, as well as nucleic acids secreted by various cell types. This review will introduce and characterize exosomes-derived ADMSCs (ADMSCs-Exo) and look at new therapies and prospective, including the limitations and outlook for therapeutic strategy. We will describe the latest research progress on myocardial repair, neuroprotection and neurotrophic effects, hepatic repair, renal repair, cutaneous repair, regeneration and other aspects using these cells.
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ISSN:1389-9333
1573-6814
1573-6814
DOI:10.1007/s10561-019-09761-y