A single injection of pregabalin induces short- and long-term beneficial effects on fear memory and anxiety-like behavior in rats with experimental type-1 diabetes mellitus

Anxiety Disorders and Posttraumatic Stress Disorders (PTSD) associated with type-1 diabetes mellitus (T1DM) are increasingly common comorbidities and the treatment is quite challenging. In that sense, evidence indicates that the anticonvulsant pregabalin is highly effective in treating severe cases...

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Bibliographic Details
Published in:	Metabolic brain disease Vol. 37; no. 4; pp. 1095 - 1110
Main Authors:	de Lima Silva, Alvaro Henrique Bernardo, Radulski, Debora Rasec, Pereira, Gabriela Saidel, Acco, Alexandra, Zanoveli, Janaina Menezes
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.04.2022 Springer Nature B.V
Subjects:	Animal memory Animals Anti-Anxiety Agents - pharmacology Anti-Anxiety Agents - therapeutic use Anticonvulsants Antioxidants Anxiety Anxiety - metabolism Anxiety disorders Anxiolytics Biochemistry Biomedical and Life Sciences Biomedicine Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 Diabetic neuropathy Extinction, Psychological - physiology Fear Fear conditioning Glutathione Hippocampus Injection Lipid peroxidation Lipids Long-term effects Memory Mental disorders Metabolic Diseases Neurology Neuroprotection Neurosciences Oncology Original Article Oxidative stress Pain Parameters Peroxidation Post traumatic stress disorder Prefrontal cortex Pregabalin - pharmacology Pregabalin - therapeutic use Psychological stress Rats Species extinction Windows (intervals) Contextual conditioned fear Oxidative stress Streptozotocin Elevated plus maze Post-traumatic stress disorder
ISSN:	0885-7490, 1573-7365, 1573-7365
Online Access:	Get full text
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