Drug-Induced Pulmonary Arterial Hypertension: Mechanisms and Clinical Management

Pulmonary arterial hypertension is a rare disease, with drug-induced causes even more uncommon, accounting for only 10% of cases in large registry series. Predisposing factors for drug-induced PAH have not been completely defined. This review summarizes drugs with definite, possible, or likely assoc...

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Published in:Cardiovascular drugs and therapy Vol. 33; no. 6; pp. 725 - 738
Main Authors: Correale, Michele, Tricarico, Lucia, Grazioli, Davide, Formica, Ennio Sascia, Petrucci, Rossella, Persichella, Paola, Di Biase, Matteo, Brunetti, Natale Daniele
Format: Journal Article
Language:English
Published: New York Springer US 01.12.2019
Springer Nature B.V
Subjects:
Algorithms
Antiretroviral therapy
Cardiology
Disease control
Drug abuse
Drugs
HIV
Human immunodeficiency virus
Hypertension
Management
Medicine
Medicine & Public Health
Pulmonary hypertension
Rare diseases
Review Article
Drug-induced pulmonary hypertension
Pulmonary arterial hypertension
Pulmonary hypertension
ISSN:0920-3206, 1573-7241, 1573-7241
Online Access:Get full text
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Summary:Pulmonary arterial hypertension is a rare disease, with drug-induced causes even more uncommon, accounting for only 10% of cases in large registry series. Predisposing factors for drug-induced PAH have not been completely defined. This review summarizes drugs with definite, possible, or likely association to pulmonary hypertension and possible mechanisms involved in the occurrence of pulmonary hypertension. Controversies on mechanisms and on their role in pathophysiology were also shown. The possible synergism between drug abuse and HIV was discussed and the possible interactions of antiretroviral therapy in HIV subjects were analyzed. Furthermore, we reported clinical findings and possible management, specific for each class of drugs, in case of drug-induced PAH. Finally, we summarized into a unified algorithm possible management of drug-induced PAH.
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ISSN:0920-3206
1573-7241
1573-7241
DOI:10.1007/s10557-019-06920-x