Quality of life of patients with thyroid eye disease: 3-year follow-up in a multidisciplinary clinic in Israel

Background Changes in the quality of life (QOL) of patients with thyroid eye disease (TED) were examined during a 3-year follow-up in a multidisciplinary eye clinic, and factors that may improve QOL were identified. Methods A retrospective review of medical records of all patients who attended the T...

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Vydané v:Graefe's archive for clinical and experimental ophthalmology Ročník 259; číslo 7; s. 2009 - 2015
Hlavní autori: Zloto, Ofira, Sagiv, Oded, Priel, Ayelet, Cukierman-Yaffe, Tali, Tirosh, Amir, Agmon-Levin, Nancy, Madgar, Shiran, Serlin, Tal, Ben Simon, Guy
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2021
Springer Nature B.V
Predmet:
Decompression
Demography
Eye diseases
Eyelid
Immunosuppressive agents
Medical records
Medical treatment
Medicine
Medicine & Public Health
Oculoplastics and Orbit
Ophthalmology
Patients
Quality of life
Rehabilitation
Steroid hormones
Strabismus
Surgery
Thyroid
Thyroid gland
Israel
European Group on Graves’ Orbitopathy
Thyroid eye disease
Graves’ orbitopathy
Quality of life
ISSN:0721-832X, 1435-702X, 1435-702X
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Shrnutí:Background Changes in the quality of life (QOL) of patients with thyroid eye disease (TED) were examined during a 3-year follow-up in a multidisciplinary eye clinic, and factors that may improve QOL were identified. Methods A retrospective review of medical records of all patients who attended the TED clinic at Sheba Medical Center, Israel, from May 2016 to May 2019 was performed. The retrieved data included demographics, comprehensive ophthalmic examination findings, clinical activity scores (CAS), laboratory test results, and QOL assessments by the Graves’ Orbitopathy QOL (GO-QOL) questionnaire. Results One hundred thirty-two TED clinic patients were examined. Thirty patients (22.72%) received medical treatment consisting of steroids according to the European Group on Graves’ Orbitopathy (EUGOGO) protocol, high-dose steroids, or immunosuppressive drugs. Twenty-eight patients (21.21%) underwent surgical rehabilitation (decompression, strabismus, or eyelid surgery). There was a significant increase in total QOL score after steroid treatment according to the EUGOGO protocol, after decompression surgery, and after strabismus surgery compared to pre-treatment total QOL ( p =0.04, p =0.021, and p =0.042, respectively, matched pairs). In addition, there were significant positive correlations between the changes in the total QOL score and the change in thyroid-stimulating immunoglobulin (TSI) as well as the change in CAS among the patients who underwent medical and surgical interventions. Conclusions QOL improved significantly after medical/surgical treatments. A change in the CAS and in the TSI may also correlate with change in QOL. Periodic evaluation of TED patients’ QOL is recommended for enhanced and more comprehensive management.
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SourceType-Scholarly Journals-1
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ISSN:0721-832X
1435-702X
1435-702X
DOI:10.1007/s00417-021-05103-5