The wound microbiota: microbial mechanisms of impaired wound healing and infection

The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing an...

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Vydáno v:Nature reviews. Microbiology Ročník 22; číslo 8; s. 507 - 521
Hlavní autoři: Uberoi, Aayushi, McCready-Vangi, Amelia, Grice, Elizabeth A
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.08.2024
Témata:
Anaerobic microorganisms
Anaerobic processes
Animals
Autoimmune diseases
Biofilms
Biofilms - growth & development
Chronic infection
Comorbidity
Diabetes mellitus
Drug resistance
Humans
Immunosuppression
Infections
Microbial contamination
Microbiota
Microorganisms
Pathogens
Resistance factors
Skin
Skin - microbiology
Skin resistance
Virulence factors
Wound Healing
Wound infection
Wound Infection - microbiology
ISSN:1740-1526, 1740-1534, 1740-1534
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Shrnutí:The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing and chronic wounds are associated with comorbidities, including diabetes, advanced age, immunosuppression and autoimmune disease. The wound microbiota can influence each stage of the multi-factorial repair process and influence the likelihood of an infection. Pathogens that commonly infect wounds, such as Staphylococcus aureus and Pseudomonas aeruginosa, express specialized virulence factors that facilitate adherence and invasion. Biofilm formation and other polymicrobial interactions contribute to host immunity evasion and resistance to antimicrobial therapies. Anaerobic organisms, fungal and viral pathogens, and emerging drug-resistant microorganisms present unique challenges for diagnosis and therapy. In this Review, we explore the current understanding of how microorganisms present in wounds impact the process of skin repair and lead to infection through their actions on the host and the other microbial wound inhabitants.
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ISSN:1740-1526
1740-1534
1740-1534
DOI:10.1038/s41579-024-01035-z