The wound microbiota: microbial mechanisms of impaired wound healing and infection
The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing an...
Uložené v:
| Vydané v: | Nature reviews. Microbiology Ročník 22; číslo 8; s. 507 - 521 |
|---|---|
| Hlavní autori: | , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
England
Nature Publishing Group
01.08.2024
|
| Predmet: | |
| ISSN: | 1740-1526, 1740-1534, 1740-1534 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing and chronic wounds are associated with comorbidities, including diabetes, advanced age, immunosuppression and autoimmune disease. The wound microbiota can influence each stage of the multi-factorial repair process and influence the likelihood of an infection. Pathogens that commonly infect wounds, such as Staphylococcus aureus and Pseudomonas aeruginosa, express specialized virulence factors that facilitate adherence and invasion. Biofilm formation and other polymicrobial interactions contribute to host immunity evasion and resistance to antimicrobial therapies. Anaerobic organisms, fungal and viral pathogens, and emerging drug-resistant microorganisms present unique challenges for diagnosis and therapy. In this Review, we explore the current understanding of how microorganisms present in wounds impact the process of skin repair and lead to infection through their actions on the host and the other microbial wound inhabitants. |
|---|---|
| AbstractList | The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing and chronic wounds are associated with comorbidities, including diabetes, advanced age, immunosuppression and autoimmune disease. The wound microbiota can influence each stage of the multi-factorial repair process and influence the likelihood of an infection. Pathogens that commonly infect wounds, such as Staphylococcus aureus and Pseudomonas aeruginosa, express specialized virulence factors that facilitate adherence and invasion. Biofilm formation and other polymicrobial interactions contribute to host immunity evasion and resistance to antimicrobial therapies. Anaerobic organisms, fungal and viral pathogens, and emerging drug-resistant microorganisms present unique challenges for diagnosis and therapy. In this Review, we explore the current understanding of how microorganisms present in wounds impact the process of skin repair and lead to infection through their actions on the host and the other microbial wound inhabitants. The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing and chronic wounds are associated with comorbidities, including diabetes, advanced age, immunosuppression and autoimmune disease. The wound microbiota can influence each stage of the multi-factorial repair process and influence the likelihood of an infection. Pathogens that commonly infect wounds, such as Staphylococcus aureus and Pseudomonas aeruginosa, express specialized virulence factors that facilitate adherence and invasion. Biofilm formation and other polymicrobial interactions contribute to host immunity evasion and resistance to antimicrobial therapies. Anaerobic organisms, fungal and viral pathogens, and emerging drug-resistant microorganisms present unique challenges for diagnosis and therapy. In this Review, we explore the current understanding of how microorganisms present in wounds impact the process of skin repair and lead to infection through their actions on the host and the other microbial wound inhabitants.In this Review, Uberoi, McCready-Vangi and Grice explore the diversity of microorganisms present in wounds and examine the mechanisms through which they invade skin tissues, impair skin repair and cause infection. The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing and chronic wounds are associated with comorbidities, including diabetes, advanced age, immunosuppression and autoimmune disease. The wound microbiota can influence each stage of the multi-factorial repair process and influence the likelihood of an infection. Pathogens that commonly infect wounds, such as Staphylococcus aureus and Pseudomonas aeruginosa, express specialized virulence factors that facilitate adherence and invasion. Biofilm formation and other polymicrobial interactions contribute to host immunity evasion and resistance to antimicrobial therapies. Anaerobic organisms, fungal and viral pathogens, and emerging drug-resistant microorganisms present unique challenges for diagnosis and therapy. In this Review, we explore the current understanding of how microorganisms present in wounds impact the process of skin repair and lead to infection through their actions on the host and the other microbial wound inhabitants.The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing and chronic wounds are associated with comorbidities, including diabetes, advanced age, immunosuppression and autoimmune disease. The wound microbiota can influence each stage of the multi-factorial repair process and influence the likelihood of an infection. Pathogens that commonly infect wounds, such as Staphylococcus aureus and Pseudomonas aeruginosa, express specialized virulence factors that facilitate adherence and invasion. Biofilm formation and other polymicrobial interactions contribute to host immunity evasion and resistance to antimicrobial therapies. Anaerobic organisms, fungal and viral pathogens, and emerging drug-resistant microorganisms present unique challenges for diagnosis and therapy. In this Review, we explore the current understanding of how microorganisms present in wounds impact the process of skin repair and lead to infection through their actions on the host and the other microbial wound inhabitants. |
| Author | Grice, Elizabeth A McCready-Vangi, Amelia Uberoi, Aayushi |
| Author_xml | – sequence: 1 givenname: Aayushi orcidid: 0000-0002-2389-5957 surname: Uberoi fullname: Uberoi, Aayushi organization: Departments of Dermatology and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA – sequence: 2 givenname: Amelia surname: McCready-Vangi fullname: McCready-Vangi, Amelia organization: Departments of Dermatology and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA – sequence: 3 givenname: Elizabeth A orcidid: 0000-0003-3939-2200 surname: Grice fullname: Grice, Elizabeth A email: egrice@pennmedicine.upenn.edu organization: Departments of Dermatology and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. egrice@pennmedicine.upenn.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38575708$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkMtKxDAUhoOMOBd9ARdScOOmmmuTupPBGwwIMq5LmouToUnGpkX06Q0448LV-fj5zuHwz8EkxGAAOEfwGkEibhJFjNclxLSEOWDl9xGYIU5hiRihkz_G1RTMU9pCiBnj-ARMiWCccShm4HW9McVnHIMuvFN9bF0c5O2BZVd4ozYyuORTEW3h_E663uj9ysbIzoX3QmZ2wRo1uBhOwbGVXTJn-7kAbw_36-VTuXp5fF7erUpFOBtKgXRLBLe41YjlSGFkVK2porAVtdWaG6FIW0lU14ToighLK0y4bRW2lGqyAFe_d3d9_BhNGhrvkjJdJ4OJY2oIJBRTimuY1ct_6jaOfcjfZUsgyrkQKFsXe2tsvdHNrnde9l_NoS3yAwSzbjo |
| CitedBy_id | crossref_primary_10_1080_07853890_2025_2530693 crossref_primary_10_1016_j_identj_2025_100909 crossref_primary_10_1016_j_nxnano_2025_100147 crossref_primary_10_1021_acsami_5c13028 crossref_primary_10_1002_smll_202501608 crossref_primary_10_3390_ph17121672 crossref_primary_10_1016_j_mtbio_2025_101871 crossref_primary_10_1016_j_mtbio_2025_101870 crossref_primary_10_1016_j_ijbiomac_2025_143418 crossref_primary_10_1080_19490976_2025_2552346 crossref_primary_10_1016_j_jddst_2025_107308 crossref_primary_10_1039_D4RA04274C crossref_primary_10_1039_D5CC04127A crossref_primary_10_1016_j_apsb_2025_03_027 crossref_primary_10_1002_adfm_202509677 crossref_primary_10_1016_j_apmt_2025_102751 crossref_primary_10_1016_j_nanoen_2025_111217 crossref_primary_10_1038_s41598_025_18174_9 crossref_primary_10_1016_j_cej_2025_164915 crossref_primary_10_1016_j_jgar_2025_05_007 crossref_primary_10_1016_j_lfs_2025_123508 crossref_primary_10_1093_bjd_ljae457 crossref_primary_10_1128_mra_00431_24 crossref_primary_10_1007_s00403_025_04202_1 crossref_primary_10_1016_j_jhazmat_2025_137429 crossref_primary_10_1016_j_carbpol_2025_123709 crossref_primary_10_1016_j_ijbiomac_2024_139428 crossref_primary_10_1016_j_mtbio_2025_101769 crossref_primary_10_1039_D5RA02557E crossref_primary_10_1002_smtd_202500015 crossref_primary_10_1016_j_cej_2025_163025 crossref_primary_10_7759_cureus_86329 crossref_primary_10_1016_j_cej_2025_167037 crossref_primary_10_3389_fmed_2024_1502337 crossref_primary_10_1016_j_apsb_2024_08_024 crossref_primary_10_1186_s12951_024_03065_4 crossref_primary_10_1016_j_pmatsci_2025_101562 crossref_primary_10_1016_j_ijbiomac_2024_136395 crossref_primary_10_3389_fmed_2025_1527736 crossref_primary_10_1021_jacs_5c10219 crossref_primary_10_53941_rmd_2025_100009 crossref_primary_10_1021_acsnano_5c08038 crossref_primary_10_1186_s12951_024_03078_z crossref_primary_10_1016_j_yexcr_2025_114646 crossref_primary_10_3390_pharmaceutics16121580 crossref_primary_10_3390_antiox14060682 crossref_primary_10_1002_INMD_20250001 crossref_primary_10_1002_adhm_202404889 crossref_primary_10_3389_fcell_2025_1625474 crossref_primary_10_1557_s43578_025_01595_7 crossref_primary_10_1016_j_cej_2024_154233 crossref_primary_10_1016_j_ijbiomac_2024_137902 crossref_primary_10_1016_j_jcis_2025_137923 crossref_primary_10_1016_j_mtbio_2025_102155 crossref_primary_10_1021_acsami_5c02386 crossref_primary_10_1016_j_jcis_2025_139007 crossref_primary_10_1002_smmd_137 crossref_primary_10_1093_burnst_tkae076 crossref_primary_10_1016_j_jcis_2025_137867 crossref_primary_10_5498_wjp_v15_i1_101563 crossref_primary_10_1002_adfm_202422554 crossref_primary_10_1039_D5TB00534E crossref_primary_10_1002_anie_202507833 crossref_primary_10_3390_ijms26135920 crossref_primary_10_1002_adma_202411229 crossref_primary_10_1007_s10924_025_03543_2 crossref_primary_10_1038_s41467_025_60935_7 crossref_primary_10_3390_polysaccharides6020045 crossref_primary_10_1016_j_aca_2025_344320 crossref_primary_10_1038_s44259_025_00115_1 crossref_primary_10_1002_adhm_202402363 crossref_primary_10_1016_j_cclet_2025_111846 crossref_primary_10_1186_s13036_024_00469_6 crossref_primary_10_3390_microorganisms13020327 crossref_primary_10_1016_j_cej_2025_162243 crossref_primary_10_1039_D5SC03456F crossref_primary_10_3390_pharmaceutics17070855 crossref_primary_10_1002_adhm_202502358 crossref_primary_10_1002_advs_202512127 crossref_primary_10_1002_smll_202405847 crossref_primary_10_1021_acsami_5c13976 crossref_primary_10_1007_s42765_025_00547_4 crossref_primary_10_1002_adfm_202418711 crossref_primary_10_1021_acs_biomac_5c01107 crossref_primary_10_1021_acsnano_5c01894 crossref_primary_10_3390_bios15030139 crossref_primary_10_1016_j_cej_2025_162931 crossref_primary_10_1186_s12951_025_03534_4 crossref_primary_10_1002_advs_202416267 crossref_primary_10_1002_smll_202501491 crossref_primary_10_1007_s42114_025_01336_8 crossref_primary_10_1021_acsami_5c05553 crossref_primary_10_3390_microorganisms13051162 crossref_primary_10_3390_nano15120919 crossref_primary_10_3390_ph18091292 crossref_primary_10_1021_acsabm_5c00586 crossref_primary_10_3390_jcm14092877 crossref_primary_10_2147_IJN_S548746 crossref_primary_10_34133_bmr_0143 crossref_primary_10_1111_iwj_70118 crossref_primary_10_1371_journal_pone_0326048 crossref_primary_10_1016_j_cej_2025_160726 crossref_primary_10_1016_j_colsurfb_2025_114712 crossref_primary_10_1002_adfm_202417415 crossref_primary_10_1021_acsami_5c10248 crossref_primary_10_1016_j_cej_2025_162108 crossref_primary_10_1055_a_2659_7184 crossref_primary_10_1016_j_ijbiomac_2025_141896 crossref_primary_10_1021_acsnano_4c18444 crossref_primary_10_1016_j_cej_2025_164086 crossref_primary_10_1093_rb_rbaf081 crossref_primary_10_1093_burnst_tkae083 crossref_primary_10_1093_burnst_tkaf051 crossref_primary_10_1172_JCI184315 crossref_primary_10_1002_adhm_202403476 crossref_primary_10_3389_fcimb_2025_1634825 crossref_primary_10_1016_j_talanta_2025_127991 crossref_primary_10_1021_acsbiomaterials_4c02045 crossref_primary_10_1021_acsami_5c08728 crossref_primary_10_3390_ijms26062544 crossref_primary_10_3390_pharmaceutics16101315 crossref_primary_10_1016_j_biomaterials_2025_123602 crossref_primary_10_1016_j_cej_2025_167361 crossref_primary_10_1016_j_jconrel_2025_113859 crossref_primary_10_3390_pharmaceutics16101313 crossref_primary_10_1002_smmd_70017 crossref_primary_10_1016_j_aquaculture_2025_742264 crossref_primary_10_1039_D4BM01734J crossref_primary_10_1016_j_jconrel_2025_113922 crossref_primary_10_1002_adfm_202425109 crossref_primary_10_1002_adfm_202513765 crossref_primary_10_1021_acsnano_5c07573 crossref_primary_10_2147_IDR_S532537 crossref_primary_10_1016_j_colsurfb_2024_114455 crossref_primary_10_1016_j_celbio_2025_100074 crossref_primary_10_1002_adma_202418731 crossref_primary_10_1016_j_colsurfb_2024_114453 crossref_primary_10_1016_j_ijbiomac_2024_135360 crossref_primary_10_3390_gels11050345 crossref_primary_10_1021_acsami_5c13537 crossref_primary_10_1016_j_cej_2024_158108 crossref_primary_10_1016_j_colsurfb_2025_115147 crossref_primary_10_1002_adhm_202501344 crossref_primary_10_1016_j_cej_2025_168316 crossref_primary_10_3390_microbiolres15040158 crossref_primary_10_1016_j_mtbio_2025_101929 crossref_primary_10_2147_IJN_S522067 crossref_primary_10_1002_ange_202507833 crossref_primary_10_1111_1751_7915_70035 crossref_primary_10_3389_fphar_2025_1580994 crossref_primary_10_1016_j_cclet_2025_110829 crossref_primary_10_1002_mabi_202500066 crossref_primary_10_3389_fcimb_2025_1610857 crossref_primary_10_1016_j_ijbiomac_2025_140797 crossref_primary_10_62347_IJYI9617 crossref_primary_10_1016_j_ijbiomac_2025_146417 crossref_primary_10_3389_fmats_2025_1573222 crossref_primary_10_1016_j_jconrel_2025_01_075 crossref_primary_10_1016_j_carbpol_2025_124401 crossref_primary_10_1016_j_bioactmat_2025_01_002 crossref_primary_10_1002_advs_202508954 crossref_primary_10_1016_j_cej_2025_166107 crossref_primary_10_1021_acsnano_4c16058 crossref_primary_10_59717_j_xinn_mater_2025_100154 crossref_primary_10_1021_acsnano_5c01134 crossref_primary_10_1016_j_cej_2024_156387 crossref_primary_10_1016_j_rechem_2025_102357 crossref_primary_10_1007_s42535_025_01298_8 crossref_primary_10_1021_jacs_5c02184 crossref_primary_10_3390_jcm13164790 crossref_primary_10_1021_acssuschemeng_5c03410 crossref_primary_10_1002_ange_202504581 crossref_primary_10_3390_jcm14134477 crossref_primary_10_1002_adhm_202501009 crossref_primary_10_1021_acsbiomaterials_4c01142 crossref_primary_10_1016_j_ijbiomac_2025_145773 crossref_primary_10_1016_j_mattod_2025_07_009 crossref_primary_10_1016_j_biomaterials_2025_123376 crossref_primary_10_1039_D4BM00547C crossref_primary_10_1038_s41467_024_53579_6 crossref_primary_10_1007_s40843_025_3459_7 crossref_primary_10_3390_plants14071059 crossref_primary_10_1002_anie_202504581 crossref_primary_10_1007_s42765_025_00568_z crossref_primary_10_1002_adhm_202501913 crossref_primary_10_1016_j_cej_2024_155722 crossref_primary_10_1080_17435889_2025_2466414 crossref_primary_10_1002_adhm_202405103 crossref_primary_10_1021_acsapm_5c00977 crossref_primary_10_1016_j_biomaterials_2024_122659 crossref_primary_10_1016_j_cej_2025_162671 crossref_primary_10_1016_j_actbio_2025_08_059 crossref_primary_10_1016_j_colsurfb_2025_115070 crossref_primary_10_1016_j_cej_2025_167777 crossref_primary_10_1016_j_carbpol_2025_123571 crossref_primary_10_1016_j_mssp_2025_109689 crossref_primary_10_1186_s12903_025_06217_6 crossref_primary_10_1016_j_bioadv_2024_214087 crossref_primary_10_1021_acsami_5c10994 crossref_primary_10_1021_acsami_5c12254 crossref_primary_10_1016_j_biomaterials_2024_123061 crossref_primary_10_1016_j_bioactmat_2025_06_004 crossref_primary_10_1016_j_carbpol_2025_123577 crossref_primary_10_1177_08853282251375205 crossref_primary_10_3390_biom15081113 crossref_primary_10_1016_j_cej_2024_155035 crossref_primary_10_26599_NR_2025_94907664 crossref_primary_10_1002_mabi_202400253 crossref_primary_10_1016_j_ijbiomac_2024_136888 crossref_primary_10_1016_j_matdes_2025_114128 crossref_primary_10_1016_j_mtbio_2025_101953 crossref_primary_10_1016_j_ijbiomac_2025_145873 crossref_primary_10_3390_nano14211693 crossref_primary_10_1016_j_microc_2025_115073 crossref_primary_10_1002_agt2_666 crossref_primary_10_1002_ardp_70072 crossref_primary_10_1016_j_carbpol_2024_123046 crossref_primary_10_1016_j_ijbiomac_2025_143471 crossref_primary_10_1007_s10856_025_06907_1 crossref_primary_10_1177_10998004241299375 crossref_primary_10_1039_D4PY01207K crossref_primary_10_1002_adma_202501817 crossref_primary_10_1016_j_bioactmat_2025_08_020 crossref_primary_10_1016_j_biomaterials_2025_123114 crossref_primary_10_1186_s12951_025_03623_4 crossref_primary_10_1016_j_ijbiomac_2024_139111 crossref_primary_10_1016_j_ijbiomac_2025_142935 crossref_primary_10_1016_j_cej_2024_153640 crossref_primary_10_1016_j_mattod_2025_08_015 crossref_primary_10_1016_j_ijbiomac_2025_140998 crossref_primary_10_12968_bjon_2024_0417 crossref_primary_10_1016_j_cej_2025_160235 crossref_primary_10_1016_j_ijbiomac_2025_147824 crossref_primary_10_1016_j_ijbiomac_2025_146855 crossref_primary_10_1080_08982104_2025_2528086 crossref_primary_10_1016_j_bcp_2025_116912 crossref_primary_10_1021_acsnano_4c13965 crossref_primary_10_26538_tjnpr_v9i7_64 crossref_primary_10_1016_j_fitote_2024_106233 crossref_primary_10_1039_D4NR02694B crossref_primary_10_1007_s12013_024_01402_w crossref_primary_10_1016_j_actbio_2025_03_015 crossref_primary_10_1016_j_chemosphere_2025_144276 crossref_primary_10_1016_j_jcis_2025_137562 crossref_primary_10_1007_s42114_024_01018_x crossref_primary_10_1016_j_carbpol_2025_123917 crossref_primary_10_1016_j_ijbiomac_2025_143314 crossref_primary_10_18699_SSMJ20250108 crossref_primary_10_1016_j_carbpol_2025_124213 crossref_primary_10_1002_adfm_202507797 crossref_primary_10_3892_ijmm_2025_5631 crossref_primary_10_1016_j_cej_2025_168614 crossref_primary_10_1016_j_bioactmat_2025_08_042 crossref_primary_10_1016_j_biotechadv_2025_108640 crossref_primary_10_1002_adma_202508538 crossref_primary_10_1016_j_ijbiomac_2024_132140 crossref_primary_10_3390_dermato5030017 crossref_primary_10_3390_ijms26188844 crossref_primary_10_1021_acsnano_5c02923 crossref_primary_10_29254_2077_4214_2025_2_177_77_101 crossref_primary_10_1016_j_bioadv_2025_214344 crossref_primary_10_1080_21688370_2025_2532229 crossref_primary_10_1002_cbdv_202500268 crossref_primary_10_1016_j_apmt_2025_102854 crossref_primary_10_1016_j_apmt_2025_102616 crossref_primary_10_1016_j_ejps_2025_107264 |
| ContentType | Journal Article |
| Copyright | 2024. Springer Nature Limited. Springer Nature Limited 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| Copyright_xml | – notice: 2024. Springer Nature Limited. – notice: Springer Nature Limited 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| DBID | CGR CUY CVF ECM EIF NPM 3V. 7QL 7RV 7U9 7X7 7XB 88A 88E 88I 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI BKSAR C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB0 LK8 M0S M1P M2P M7N M7P NAPCQ P64 PCBAR PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 |
| DOI | 10.1038/s41579-024-01035-z |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Nursing & Allied Health Database Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts Earth, Atmospheric & Aquatic Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest Central Essentials SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest Central Student MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1740-1534 |
| EndPage | 521 |
| ExternalDocumentID | 38575708 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: NIAMS NIH HHS grantid: K99 AR081404 |
| GroupedDBID | --- .55 0R~ 123 29M 36B 39C 4.4 53G 70F 7RV 7X7 88E 88I 8AO 8C1 8CJ 8FE 8FH 8FI 8FJ 8R4 8R5 AARCD AAWYQ AAYZH ABAWZ ABDBF ABJNI ABLJU ABUWG ACGFO ACGFS ACMJI ACPRK ACUHS ADBBV ADFRT AENEX AEUYN AFBBN AFKRA AFRAH AFSHS AGAYW AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC BBNVY BENPR BHPHI BKEYQ BKKNO BKSAR BPHCQ BVXVI CCPQU CGR CS3 CUY CVF D1J DB5 DU5 DWQXO EAD EAP EAS EBS ECM EE. EIF EJD EMB EMK EMOBN ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR INH INR ITC LGEZI LK8 LOTEE M1P M2P M7P MM. N9A NADUK NAPCQ NNMJJ NPM NXXTH O9- ODYON P2P PCBAR PHGZT PQQKQ PROAC PSQYO Q2X QF4 QM4 QN7 QO4 RNR RNT RNTTT SHXYY SIXXV SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP WOW X7M 3V. 7QL 7U9 7XB 88A 8FD 8FK ABFSG ACSTC AEZWR AFANA AFHIU AGSTI AHWEU AIXLP ALPWD ATHPR C1K FR3 H94 K9. M7N NFIDA P64 PHGZM PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U RC3 7X8 PUEGO |
| ID | FETCH-LOGICAL-c375t-81db387f2bd15c37c21ec9d4c40b89fdd7e8c3b6a19933d638f46237fbc2f44d3 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 360 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001196863700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1740-1526 1740-1534 |
| IngestDate | Sun Sep 28 01:04:59 EDT 2025 Mon Oct 06 17:03:36 EDT 2025 Fri Mar 28 01:32:02 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | 2024. Springer Nature Limited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c375t-81db387f2bd15c37c21ec9d4c40b89fdd7e8c3b6a19933d638f46237fbc2f44d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0002-2389-5957 0000-0003-3939-2200 |
| PMID | 38575708 |
| PQID | 3081477881 |
| PQPubID | 27584 |
| PageCount | 15 |
| ParticipantIDs | proquest_miscellaneous_3034244290 proquest_journals_3081477881 pubmed_primary_38575708 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-08-01 |
| PublicationDateYYYYMMDD | 2024-08-01 |
| PublicationDate_xml | – month: 08 year: 2024 text: 2024-08-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Nature reviews. Microbiology |
| PublicationTitleAlternate | Nat Rev Microbiol |
| PublicationYear | 2024 |
| Publisher | Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group |
| SSID | ssj0025572 |
| Score | 2.749355 |
| SecondaryResourceType | review_article |
| Snippet | The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 507 |
| SubjectTerms | Anaerobic microorganisms Anaerobic processes Animals Autoimmune diseases Biofilms Biofilms - growth & development Chronic infection Comorbidity Diabetes mellitus Drug resistance Humans Immunosuppression Infections Microbial contamination Microbiota Microorganisms Pathogens Resistance factors Skin Skin - microbiology Skin resistance Virulence factors Wound Healing Wound infection Wound Infection - microbiology |
| Title | The wound microbiota: microbial mechanisms of impaired wound healing and infection |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38575708 https://www.proquest.com/docview/3081477881 https://www.proquest.com/docview/3034244290 |
| Volume | 22 |
| WOSCitedRecordID | wos001196863700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB7xKFIvlHeXxypIvVoksYPtXipAIC6sohVUe1v5Ke1hswtZiuivZybJwqlcehk5D0eRPfZ8tmfmA_hhreGFj57x6C0T3glmfMyY1jmCW-4NV7Yhm5CDgRqNdNltuNWdW-VyTmwmaj9ztEd-xtF2CUnJz3_NHxmxRtHpakehsQrrlCWBN6575fuCqyga8iYE3SlDO3XeBc2kXJ3VaLikZmihGDEdFOzvvyFmY2puvv3vT27BZgcyk4tWK7ZhJVQ7sNHSTr7uwhB1I3khPqVkOmkTMS3Mz2UZK04DxQNP6mmdzGJCgZQ4MfquCkFLtHeJwfLSlavag4eb6_urW9ZxKzDHZbFgCFMtVzLm1mcF3nJ5Fpz2wonUKh29l0E5bs8NOfhxj6M0CkRKMlqXRyE834e1alaF75CoVBvBnVTB4erMRpMFb4wuHK5csE9kD46XjTXuBkg9_mipHpy-P0bVpvMKU4XZM73DKQwv12kPDtoOGc_bHBxjTsyiMlWHn3_8CL7mTR-Tx94xrC2ensMJfHF_FpP6qQ-rcvib5Eg2UqFUV1kf1i-vB-UQr-7yst_oFMpBefcGRS3QIw |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VpRVcoA-gC20JUjlam8TO2kZCCEGrVi0rVBXUW-qntIfNts2WqvwofiMzeZQT3HrgZiWxpcRf5puxZ_wB7FpreOGjZzx6y4R3ghkfM6Z1js4t94Yr24hNyMlEnZ3pr0vwq6-FobTK3iY2htrPHa2Rjzhyl5B0-PmHi0tGqlG0u9pLaLSwOAq3Nxiy1e8PP-P8vs3z_b3TTwesUxVgjstiwdBBs1zJmFufFXjJ5Vlw2gsnUqt09F4G5bgdG0pt4x7xGQX6CDJal0chPMdxH8BDtOMZpZDJk-93AV5RNGJR6OSnDHlx3BXppFyNaiRKqRkyIiNlhYL9_LtL21Db_tP_7aOswpPOiU4-tqhfg6VQrcNKK6t5uwEniP3khvSiktm0PWhqYd71bew4C1TvPK1ndTKPCRWKouH3XRdynZHPE4PtPlWtegbf7uWFnsOgmldhExKVaiO4kyo4jD5tNFnwxujCYWSGfCGHsNVPTtkZgLr8MzNDeHN3G39d2o8xVZhf0zOcygxznQ7hRQuA8qI9Y6TkpJwqU_Xy34O_hkcHp1-Oy-PDydEreJw3-KLsxC0YLK6uwzYsux-LaX210yA1gfP7RsFvCDYnFA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1NT9wwEB0BLVUvlLZAFyikUnu0Nhs72K6EUAVdFYFWqKISt9Sf0h42uyULCH4av64z-YATvXHozYpjS8mM_Z7tGT-Az9YanvvoGY_eMuGdYMbHAdM6Q3LLveHK1mITcjRSFxf6bAHuu1wYCqvs5sR6ovZTR3vkfY7YJSRdft6PbVjE2dHwYPaHkYIUnbR2chqNi5yE2xtcvlX7x0do6y9ZNvx-fviDtQoDzHGZzxmSNcuVjJn1gxwfuWwQnPbCidQqHb2XQTlu9wyFuXGPvhoF8gUZrcuiEJ5jv4vwQnKsoSz1w4fwEmTqtXAUEv6UIUbutQk7KVf9CkFTaoboyEhlIWd3T9PbGuaGb_7nH7QKKy25Tr41o-EtLITyHSw3cpu37-EnjonkhnSkksm4uYBqbr52ZWw4CZQHPa4mVTKNCSWQIiD4tglRasT5xGC5C2Er1-DXs3zQOiyV0zJ8gESl2gjupAoOV6U2mkHwxujc4YoNcUT2YLszVNFODFXxaKUefHqoxiFN5zSmDNMreodT-mGm0x5sNM5QzJq7RwpOiqoyVZv_7nwXXqHxi9Pj0ckWvM5qV6OgxW1Yml9ehY_w0l3Px9XlTu20Cfx-bif4C8gbL28 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+wound+microbiota%3A+microbial+mechanisms+of+impaired+wound+healing+and+infection&rft.jtitle=Nature+reviews.+Microbiology&rft.au=Uberoi%2C+Aayushi&rft.au=McCready-Vangi%2C+Amelia&rft.au=Grice%2C+Elizabeth+A&rft.date=2024-08-01&rft.pub=Nature+Publishing+Group&rft.issn=1740-1526&rft.eissn=1740-1534&rft.volume=22&rft.issue=8&rft.spage=507&rft.epage=521&rft_id=info:doi/10.1038%2Fs41579-024-01035-z&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1740-1526&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1740-1526&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1740-1526&client=summon |