Bad to the Bone: The Role of the Insulin-Like Growth Factor Axis in Osseous Metastasis

Bone metastases are a frequent complication of cancer that are associated with considerable morbidity. Current treatments may temporarily palliate the symptoms of bone metastases but often fail to delay their progression. Bones provide a permissive environment because they are characterized by dynam...

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Bibliographic Details

Published in:	Clinical cancer research Vol. 25; no. 12; p. 3479
Main Authors:	Rieunier, Guillaume, Wu, Xiaoning, Macaulay, Valentine M, Lee, Adrian V, Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas
Format:	Journal Article
Language:	English
Published:	United States 15.06.2019
Subjects:	Animals Antineoplastic Agents - pharmacology Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - secondary Bone Remodeling Disease Models, Animal Humans Insulin-Like Growth Factor I - antagonists & inhibitors Insulin-Like Growth Factor I - metabolism Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - metabolism
ISSN:	1557-3265, 1557-3265
Online Access:	Get more information
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