Rare ocular toxicity induced by pertuzumab/QL1209 in healthy chinese subjects: case reports and whole-exome sequencing analysis

Summary Pertuzumab is a recombinant anti-HER2 humanized monoclonal antibody widely used for the adjuvant treatment of HER2-positive breast cancer. Its safety is well established with the most common adverse effects being diarrhea and rash. To our knowledge, severe pertuzumab-induced ocular adverse e...

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Bibliographic Details
Published in:	Investigational new drugs Vol. 40; no. 4; pp. 861 - 867
Main Authors:	Ma, Junlong, Chen, Wenjing, Hu, Zhanqing, Huang, Jie, Guo, Chengxian, Zou, Chan, Yang, Guoping
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.08.2022 Springer Nature B.V
Subjects:	1-Phosphatidylinositol 3-kinase AKT protein Breast cancer Calcium-sensing receptors Case Report Case reports Diarrhea DNA sequencing Encyclopedias ErbB-2 protein Genes Genetic factors Genomes Immunotherapy MAP kinase Medicine Medicine & Public Health Monoclonal antibodies Oncology Optic nerve Pharmacology/Toxicology Phosphorylation Raf protein Sequence analysis Targeted cancer therapy TOR protein Toxicity Vision Breast cancer Ocular toxicity Pertuzumab WES Genetic mechanisms
ISSN:	0167-6997, 1573-0646, 1573-0646
Online Access:	Get full text
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