Polygenic scores in cancer

Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer have been identified. The relative risk associated with individual variants is small and of limited clinical significance. However, the combine...

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Veröffentlicht in:	Nature reviews. Cancer Jg. 23; H. 9; S. 619 - 630
Hauptverfasser:	Yang, Xin, Kar, Siddhartha, Antoniou, Antonis C, Pharoah, Paul D P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.09.2023
Schlagworte:	Alleles Cancer Clinical Relevance Clinical trials Genome-wide association studies Genome-Wide Association Study Genomes Humans Neoplasms - genetics Prediction models Reviews Therapeutic applications
ISSN:	1474-175X, 1474-1768, 1474-1768
Online-Zugang:	Volltext
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