Arnicolide D: a multi-targeted anticancer sesquiterpene lactone—preclinical efficacy and mechanistic insights

Arnicolide D, a potent sesquiterpene lactone from Centipeda minima , has emerged as a promising anticancer candidate, demonstrating significant efficacy in inhibiting cancer cell proliferation, inducing apoptosis, and suppressing metastasis across various cancer models. This comprehensive study delv...

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Vydané v:	Naunyn-Schmiedeberg's archives of pharmacology Ročník 397; číslo 9; s. 6317 - 6336
Hlavní autori:	Mangalpady, Shivaprasad Shetty, Peña-Corona, Sheila I., Borbolla-Jiménez, Fabiola, Kaverikana, Rajesh, Shetty, Shobhitha, Shet, Vinayaka Babu, Almarhoon, Zainab M., Calina, Daniela, Leyva-Gómez, Gerardo, Sharifi-Rad, Javad
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2024 Springer Nature B.V
Predmet:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Apoptosis - drug effects Archives & records Asthma Biomedical and Life Sciences Biomedicine Breast cancer Breast carcinoma Cancer therapies Cell culture Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemistry Clinical trials Colon Colon cancer Colorectal cancer Cytotoxicity Dosage Herbal medicine Humans Infections Keywords Lactones - pharmacology Lactones - therapeutic use Medical Subject Headings-MeSH Metastases Metastasis Molecular modelling Nasopharyngeal carcinoma Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neurosciences Pharmacokinetics Pharmacology Pharmacology/Toxicology Pharmacy Prostate cancer Review Sesquiterpenes - pharmacokinetics Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Signal Transduction - drug effects Stat3 protein Throat cancer TOR protein Toxicity testing Tumor cell lines Anti-cancer mechanisms Sesquiterpene lactone, Src degradation PI3K/AKT/mTOR pathway Arnicolide D Apoptosis Centipeda minima
ISSN:	0028-1298, 1432-1912, 1432-1912
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Popis
Shrnutí:	Arnicolide D, a potent sesquiterpene lactone from Centipeda minima , has emerged as a promising anticancer candidate, demonstrating significant efficacy in inhibiting cancer cell proliferation, inducing apoptosis, and suppressing metastasis across various cancer models. This comprehensive study delves into the molecular underpinnings of Arnicolide D’s anticancer actions, emphasizing its impact on key signaling pathways such as PI3K/AKT/mTOR and STAT3, and its role in modulating cell cycle and survival mechanisms. Quantitative data from preclinical studies reveal Arnicolide D’s dose-dependent cytotoxicity against cancer cell lines, including nasopharyngeal carcinoma, triple-negative breast cancer, and human colon carcinoma, showcasing its broad-spectrum anticancer potential. Given its multifaceted mechanisms and preclinical efficacy, Arnicolide D warrants further investigation in clinical settings to validate its therapeutic utility against cancer. The evidence presented underscores the need for rigorous pharmacokinetic and toxicological studies to establish safe dosing parameters for future clinical trials.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0028-1298 1432-1912 1432-1912
DOI:	10.1007/s00210-024-03095-7