Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy

Diabetic retinopathy (DR) is a vision-impairing complication of diabetes, damaging the retinal microcirculatory system. Overexpression of VEGF (vascular endothelial growth factor) is implicated in the pathogenesis of DR. Human antigen R (HuR) is an RNA-binding protein that favorably regulates VEGF p...

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Bibliographic Details
Published in:	Drug delivery and translational research Vol. 13; no. 6; pp. 1675 - 1698
Main Authors:	Supe, Shibani, Upadhya, Archana, Tripathi, Santosh, Dighe, Vikas, Singh, Kavita
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.06.2023 Springer Nature B.V
Subjects:	Animals Biomedical and Life Sciences Biomedicine Diabetes Mellitus, Experimental Diabetic Retinopathy ELAV-Like Protein 1 - genetics Humans Liposomes - chemistry Microcirculation Original Article Pharmaceutical Sciences/Technology Polyethyleneimine - chemistry Rats Rats, Wistar RNA, Messenger RNA, Small Interfering Vascular Endothelial Growth Factor A - metabolism Diabetic retinopathy Polyethylenimine siRNA Lipopolyplexes VEGF-A HuR/ELAV
ISSN:	2190-393X, 2190-3948, 2190-3948
Online Access:	Get full text
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