Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects

Background Selonsertib is a first-in-class inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with therapeutic potential for fibrotic diseases. This phase I study evaluated the safety, tolerability, pharmacokinetics (PK), and food effect of selonsertib in healthy subjects. Methods This was a d...

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Vydáno v:	Clinical pharmacokinetics Ročník 59; číslo 9; s. 1109 - 1117
Hlavní autoři:	Nelson, Cara H., Etchevers, Kim, Yi, Saili, Breckenridge, David, Hepner, Mischa, Patel, Uptal, Ling, John, Mathias, Anita
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cham Springer International Publishing 01.09.2020 Springer Nature B.V
Témata:	Apoptosis Chemokines Drug dosages Food Inflammation Internal Medicine Kinases Laboratories Ligands Medicine Medicine & Public Health Original Research Article Oxidative stress Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Phosphorylation Urine United States > US
ISSN:	0312-5963, 1179-1926, 1179-1926
On-line přístup:	Získat plný text
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