Bottom-up synthetic immunology

Infectious diseases and cancer evade immune surveillance using similar mechanisms. Targeting immune mechanisms using common strategies thus represents a promising avenue to improve prevention and treatment. Synthetic immunology can provide such strategies by applying engineering principles from synt...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Nature nanotechnology Ročník 19; číslo 11; s. 1587 - 1596
Hlavní autori: Göpfrich, Kerstin, Platten, Michael, Frischknecht, Friedrich, Fackler, Oliver T.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 01.11.2024
Nature Publishing Group
Predmet:
631/61/350/354
631/61/350/877
639/925/926/1050
706/648
Animals
Biology
Cancer
Chemistry and Materials Science
Communicable Diseases - immunology
Communicable Diseases - therapy
Engineers
Genetic engineering
Genetic Engineering - methods
Humans
Immune system
Immunology
Immunosurveillance
Infectious diseases
Materials Science
Modular engineering
Nanotechnology
Nanotechnology - methods
Nanotechnology and Microengineering
Neoplasms - immunology
Neoplasms - therapy
Perspective
Precision medicine
Prevention
Synthetic biology
Synthetic Biology - methods
ISSN:1748-3387, 1748-3395, 1748-3395
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Infectious diseases and cancer evade immune surveillance using similar mechanisms. Targeting immune mechanisms using common strategies thus represents a promising avenue to improve prevention and treatment. Synthetic immunology can provide such strategies by applying engineering principles from synthetic biology to immunology. Synthetic biologists engineer cells by top-down genetic manipulation or bottom-up assembly from nanoscale building blocks. Recent successes in treating advanced tumours and diseases using genetically engineered immune cells highlight the power of the top-down synthetic immunology approach. However, genetic immune engineering is mostly limited to ex vivo applications and is subject to complex counter-regulation inherent to immune functions. Bottom-up synthetic biology can harness the rich nanotechnology toolbox to engineer molecular and cellular systems from scratch and equip them with desired functions. These are beginning to be tailored to perform targeted immune functions and should hence allow intervention strategies by rational design. In this Perspective we conceptualize bottom-up synthetic immunology as a new frontier field that uses nanotechnology for crucial innovations in therapy and the prevention of infectious diseases and cancer. This Perspective highlights bottom-up molecular engineering and modular nanobiotechnological approaches for developing effective immunotherapeutics and their potential in personalized medicine.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1748-3387
1748-3395
1748-3395
DOI:10.1038/s41565-024-01744-9