The use of medical grade cannabis in Italy for drug-resistant epilepsy: a case series

In Italy, medical grade cannabis (MGC) can be prescribed for different medical conditions, including drug-resistant epilepsy (DRE), once standard and approved therapies have failed, or caused non-tolerable side effects. Here, we present a retrospective case series report of five patients with DRE wh...

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Veröffentlicht in:Neurological sciences Jg. 41; H. 3; S. 695 - 698
Hauptverfasser: Pane, Chiara, Saccà, Francesco
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Cham Springer International Publishing 01.03.2020
Springer Nature B.V
Schlagworte:
Brief Communication
Cannabinoids
Cannabis
Drug resistance
Epilepsy
ISO standards
Marijuana
Medicine
Medicine & Public Health
Mood
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Olive oil
Patients
Psychiatry
Seizures
Side effects
Sleep
Well being
Italy
West syndrome
Absence
Cannabis
Oil extract
ISSN:1590-1874, 1590-3478, 1590-3478
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Abstract In Italy, medical grade cannabis (MGC) can be prescribed for different medical conditions, including drug-resistant epilepsy (DRE), once standard and approved therapies have failed, or caused non-tolerable side effects. Here, we present a retrospective case series report of five patients with DRE who started therapy with MGC. Authorized ISO 9001:2008 pharmacies prepared MGC according to Italian laws. Olive oil extracts (OOEs) were prepared following standard extraction protocols, and cannabinoids were measured on each OOE to check for successful extraction.After treatment with MGC, all patients reported a reduction in seizure frequency and severity, and some reported improved mood, sleep quality, and general well-being without relevant side effects. Despite the small sample size and open-label nature of the data, we show that MGC may be successfully used to treat DRE. This is especially true when considering that no valid therapeutic option exists for these patients and that MGC was extremely well tolerated.
AbstractList In Italy, medical grade cannabis (MGC) can be prescribed for different medical conditions, including drug-resistant epilepsy (DRE), once standard and approved therapies have failed, or caused non-tolerable side effects. Here, we present a retrospective case series report of five patients with DRE who started therapy with MGC. Authorized ISO 9001:2008 pharmacies prepared MGC according to Italian laws. Olive oil extracts (OOEs) were prepared following standard extraction protocols, and cannabinoids were measured on each OOE to check for successful extraction.After treatment with MGC, all patients reported a reduction in seizure frequency and severity, and some reported improved mood, sleep quality, and general well-being without relevant side effects. Despite the small sample size and open-label nature of the data, we show that MGC may be successfully used to treat DRE. This is especially true when considering that no valid therapeutic option exists for these patients and that MGC was extremely well tolerated.
In Italy, medical grade cannabis (MGC) can be prescribed for different medical conditions, including drug-resistant epilepsy (DRE), once standard and approved therapies have failed, or caused non-tolerable side effects. Here, we present a retrospective case series report of five patients with DRE who started therapy with MGC. Authorized ISO 9001:2008 pharmacies prepared MGC according to Italian laws. Olive oil extracts (OOEs) were prepared following standard extraction protocols, and cannabinoids were measured on each OOE to check for successful extraction.After treatment with MGC, all patients reported a reduction in seizure frequency and severity, and some reported improved mood, sleep quality, and general well-being without relevant side effects. Despite the small sample size and open-label nature of the data, we show that MGC may be successfully used to treat DRE. This is especially true when considering that no valid therapeutic option exists for these patients and that MGC was extremely well tolerated.In Italy, medical grade cannabis (MGC) can be prescribed for different medical conditions, including drug-resistant epilepsy (DRE), once standard and approved therapies have failed, or caused non-tolerable side effects. Here, we present a retrospective case series report of five patients with DRE who started therapy with MGC. Authorized ISO 9001:2008 pharmacies prepared MGC according to Italian laws. Olive oil extracts (OOEs) were prepared following standard extraction protocols, and cannabinoids were measured on each OOE to check for successful extraction.After treatment with MGC, all patients reported a reduction in seizure frequency and severity, and some reported improved mood, sleep quality, and general well-being without relevant side effects. Despite the small sample size and open-label nature of the data, we show that MGC may be successfully used to treat DRE. This is especially true when considering that no valid therapeutic option exists for these patients and that MGC was extremely well tolerated.
Author Pane, Chiara
Saccà, Francesco
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  orcidid: 0000-0002-3459-2644
  surname: Pane
  fullname: Pane, Chiara
  organization: Department of Neurosciences and Reproductive and Odontostomatological Sciences, University “Federico II”
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  givenname: Francesco
  orcidid: 0000-0002-1323-6317
  surname: Saccà
  fullname: Saccà, Francesco
  email: francesco.sacca@unina.it
  organization: Department of Neurosciences and Reproductive and Odontostomatological Sciences, University “Federico II”
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CitedBy_id crossref_primary_10_1093_pm_pnab245
crossref_primary_10_1007_s10072_020_04559_3
crossref_primary_10_1016_j_ebr_2022_100579
crossref_primary_10_1111_apa_70140
crossref_primary_10_3389_fphar_2024_1411631
Cites_doi 10.1126/science.1088208
10.1016/S0014-2999(98)00392-6
10.3389/fnut.2019.00112
10.1111/epi.12610
10.1016/j.eplepsyres.2019.03.015
10.1016/j.yebeh.2016.12.032
10.1111/epi.13709
10.1515/cclm-2017-0758
10.1111/j.1528-1167.2009.02397.x
10.1016/j.jns.2016.07.059
10.1001/jama.2015.6358
ContentType Journal Article
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Absence
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Oil extract
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References Pacifici, Marchei, Salvatore, Guandalini, Busardò, Pichini (CR6) 2018; 56
Laux, Bebin, Checketts, Chez, Flamini, Marsh, Miller, Nichol, Park, Segal, Seltzer, Szaflarski, Thiele, Weinstock (CR9) 2019; 154
Ben-Shabat, Fride, Sheskin, Tamiri, Rhee, Vogel, Bisogno, de Petrocellis, di Marzo, Mechoulam (CR11) 1998; 353
CR4
Marchiò, Roli, Lucchi, Costa, Borghi, Iughetti, Trenti, Guerra, Biagini (CR12) 2019; 6
Marsicano, Goodenough, Monory, Hermann, Eder, Cannich, Azad, Cascio, Gutiérrez, van der Stelt, López-Rodriguez, Casanova, Schütz, Zieglgänsberger, di Marzo, Behl, Lutz (CR10) 2003; 302
Maa, Figi (CR2) 2014; 55
Kwan, Arzimanoglou, Berg, Brodie, Allen Hauser, Mathern, Moshé, Perucca, Wiebe, French (CR1) 2010; 51
Whiting, Wolff, Deshpande, Di Nisio, Duffy, Hernandez, Keurentjes, Lang, Misso, Ryder, Schmidlkofer, Westwood, Kleijnen (CR3) 2015; 313
Sulak, Saneto, Goldstein (CR8) 2017; 70
Saccà, Pane, Carotenuto, Massarelli, Lanzillo, Florio, Brescia (CR5) 2016; 368
Scheffer, Berkovic, Capovilla, Connolly, French, Guilhoto, Hirsch, Jain, Mathern, Moshé, Nordli, Perucca, Tomson, Wiebe, Zhang, Zuberi (CR7) 2017; 58
R Pacifici (4162_CR6) 2018; 56
M Marchiò (4162_CR12) 2019; 6
IE Scheffer (4162_CR7) 2017; 58
LC Laux (4162_CR9) 2019; 154
S Ben-Shabat (4162_CR11) 1998; 353
P Kwan (4162_CR1) 2010; 51
D Sulak (4162_CR8) 2017; 70
G Marsicano (4162_CR10) 2003; 302
PF Whiting (4162_CR3) 2015; 313
F Saccà (4162_CR5) 2016; 368
E Maa (4162_CR2) 2014; 55
4162_CR4
References_xml – volume: 302
  start-page: 84
  issue: 5642
  year: 2003
  end-page: 88
  ident: CR10
  article-title: CB1cannabinoid receptors and on-demand defence against excitotoxicity
  publication-title: Science
  doi: 10.1126/science.1088208
– volume: 353
  start-page: 23
  year: 1998
  end-page: 31
  ident: CR11
  article-title: An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
  publication-title: Eur J Pharmacol.
  doi: 10.1016/S0014-2999(98)00392-6
– volume: 6
  start-page: 112
  year: 2019
  ident: CR12
  article-title: Ghrelin plasma levels after 1 year of ketogenic diet in children with refractory epilepsy
  publication-title: Front Nutr
  doi: 10.3389/fnut.2019.00112
– volume: 55
  start-page: 783
  year: 2014
  end-page: 786
  ident: CR2
  article-title: The case for medical marijuana in epilepsy
  publication-title: Epilepsia
  doi: 10.1111/epi.12610
– volume: 154
  start-page: 13
  year: 2019
  end-page: 20
  ident: CR9
  article-title: Long-term safety and efficacy of cannabidiol in children and adults with treatment resistant Lennox-Gastaut syndrome or Dravet syndrome: expanded access program results
  publication-title: Epilepsy Res
  doi: 10.1016/j.eplepsyres.2019.03.015
– ident: CR4
– volume: 70
  start-page: 328
  issue: Pt B
  year: 2017
  end-page: 333
  ident: CR8
  article-title: The current status of artisanal cannabis for the treatment of epilepsy in the United States
  publication-title: Epilepsy Behav
  doi: 10.1016/j.yebeh.2016.12.032
– volume: 58
  start-page: 512
  year: 2017
  end-page: 521
  ident: CR7
  article-title: ILAE classification of the epilepsies position paper of the ILAE Commission for Classification and Terminology
  publication-title: Epilepsia.
  doi: 10.1111/epi.13709
– volume: 56
  start-page: 94
  year: 2018
  end-page: 96
  ident: CR6
  article-title: Evaluation of long-term stability of cannabinoids in standardized preparations of cannabis flowering tops and cannabis oil by ultra-high-performance liquid chromatography tandem mass spectrometry
  publication-title: Clin Chem Lab Med
  doi: 10.1515/cclm-2017-0758
– volume: 51
  start-page: 1069
  year: 2010
  end-page: 1077
  ident: CR1
  article-title: Definition of drug resistant epilepsy: consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2009.02397.x
– volume: 368
  start-page: 349
  year: 2016
  end-page: 351
  ident: CR5
  article-title: The use of medical-grade cannabis in patients non-responders to Nabiximols
  publication-title: J Neurol Sci.
  doi: 10.1016/j.jns.2016.07.059
– volume: 313
  start-page: 2456
  year: 2015
  end-page: 2473
  ident: CR3
  article-title: Cannabinoids for medical use: a systematic review and meta-analysis
  publication-title: JAMA
  doi: 10.1001/jama.2015.6358
– volume: 353
  start-page: 23
  year: 1998
  ident: 4162_CR11
  publication-title: Eur J Pharmacol.
  doi: 10.1016/S0014-2999(98)00392-6
– volume: 55
  start-page: 783
  year: 2014
  ident: 4162_CR2
  publication-title: Epilepsia
  doi: 10.1111/epi.12610
– volume: 154
  start-page: 13
  year: 2019
  ident: 4162_CR9
  publication-title: Epilepsy Res
  doi: 10.1016/j.eplepsyres.2019.03.015
– volume: 302
  start-page: 84
  issue: 5642
  year: 2003
  ident: 4162_CR10
  publication-title: Science
  doi: 10.1126/science.1088208
– volume: 51
  start-page: 1069
  year: 2010
  ident: 4162_CR1
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2009.02397.x
– volume: 70
  start-page: 328
  issue: Pt B
  year: 2017
  ident: 4162_CR8
  publication-title: Epilepsy Behav
  doi: 10.1016/j.yebeh.2016.12.032
– volume: 313
  start-page: 2456
  year: 2015
  ident: 4162_CR3
  publication-title: JAMA
  doi: 10.1001/jama.2015.6358
– volume: 6
  start-page: 112
  year: 2019
  ident: 4162_CR12
  publication-title: Front Nutr
  doi: 10.3389/fnut.2019.00112
– ident: 4162_CR4
– volume: 368
  start-page: 349
  year: 2016
  ident: 4162_CR5
  publication-title: J Neurol Sci.
  doi: 10.1016/j.jns.2016.07.059
– volume: 56
  start-page: 94
  year: 2018
  ident: 4162_CR6
  publication-title: Clin Chem Lab Med
  doi: 10.1515/cclm-2017-0758
– volume: 58
  start-page: 512
  year: 2017
  ident: 4162_CR7
  publication-title: Epilepsia.
  doi: 10.1111/epi.13709
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Snippet In Italy, medical grade cannabis (MGC) can be prescribed for different medical conditions, including drug-resistant epilepsy (DRE), once standard and approved...
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SubjectTerms Brief Communication
Cannabinoids
Cannabis
Drug resistance
Epilepsy
ISO standards
Marijuana
Medicine
Medicine & Public Health
Mood
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Olive oil
Patients
Psychiatry
Seizures
Side effects
Sleep
Well being
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Title The use of medical grade cannabis in Italy for drug-resistant epilepsy: a case series
URI https://link.springer.com/article/10.1007/s10072-019-04162-1
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