Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades

Patients undergoing radiation therapy experience debilitating side effects because of toxicity arising from radiation-induced DNA strand breaks in normal peritumoural cells. Here, inspired by the ability of tardigrades to resist extreme radiation through the expression of a damage-suppressor protein...

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Vydané v:	Nature biomedical engineering Ročník 9; číslo 8; s. 1240
Hlavní autori:	Kirtane, Ameya R, Bi, Jianling, Rajesh, Netra U, Tang, Chaoyang, Jimenez, Miguel, Witt, Emily, McGovern, Megan K, Cafi, Arielle B, Hatfield, Samual J, Rosenstock, Lauren, Becker, Sarah L, Machado, Nicole, Venkatachalam, Veena, Freitas, Dylan, Huang, Xisha, Chan, Alvin, Lopes, Aaron, Kim, Hyunjoon, Kim, Nayoon, Collins, Joy E, Howard, Michelle E, Manchkanti, Srija, Hong, Theodore S, Byrne, James D, Traverso, Giovanni
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.08.2025
Predmet:	Animals DNA Damage Humans Male Mice Nanoparticles - chemistry Radiation-Protective Agents RNA, Messenger - administration & dosage RNA, Messenger - genetics RNA, Messenger - metabolism Tardigrada - genetics Tardigrada - metabolism
ISSN:	2157-846X, 2157-846X
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