Acquired Resistance to BET-PROTACs (Proteolysis-Targeting Chimeras) Caused by Genomic Alterations in Core Components of E3 Ligase Complexes

Proteolysis-targeting chimeras (PROTAC) are bifunctional molecules that hijack endogenous E3 ubiquitin ligases to induce ubiquitination and subsequent degradation of protein of interest. Recently, it has been shown that PROTACs with robust and activities and, in some cases, drug-like pharmaceutical...

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Veröffentlicht in:	Molecular cancer therapeutics Jg. 18; H. 7; S. 1302
Hauptverfasser:	Zhang, Lu, Riley-Gillis, Bridget, Vijay, Priyanka, Shen, Yu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2019
Schlagworte:	Cell Line, Tumor Genomics - methods Humans Proteolysis Ubiquitin-Protein Ligases - metabolism
ISSN:	1538-8514, 1538-8514
Online-Zugang:	Weitere Angaben
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