Acquired Resistance to BET-PROTACs (Proteolysis-Targeting Chimeras) Caused by Genomic Alterations in Core Components of E3 Ligase Complexes

Proteolysis-targeting chimeras (PROTAC) are bifunctional molecules that hijack endogenous E3 ubiquitin ligases to induce ubiquitination and subsequent degradation of protein of interest. Recently, it has been shown that PROTACs with robust and activities and, in some cases, drug-like pharmaceutical...

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Bibliographic Details

Published in:	Molecular cancer therapeutics Vol. 18; no. 7; p. 1302
Main Authors:	Zhang, Lu, Riley-Gillis, Bridget, Vijay, Priyanka, Shen, Yu
Format:	Journal Article
Language:	English
Published:	United States 01.07.2019
Subjects:	Cell Line, Tumor Genomics - methods Humans Proteolysis Ubiquitin-Protein Ligases - metabolism
ISSN:	1538-8514, 1538-8514
Online Access:	Get more information
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