Dopamine D1 Receptor in the Nucleus Accumbens Modulates the Emergence from Propofol Anesthesia in Rat

It has been reported that systemic activation of D1 receptors promotes emergence from isoflurane-induced unconsciousness, suggesting that the central dopaminergic system is involved in the process of recovering from general anesthesia. The nucleus accumbens (NAc) contains abundant GABAergic medium s...

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Bibliographic Details
Published in:	Neurochemical research Vol. 46; no. 6; pp. 1435 - 1446
Main Authors:	Zhang, Yi, Gui, Huan, Duan, Zikun, Yu, Tian, Zhang, Jie, Liang, Xiaoli, Liu, Chengxi
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.06.2021 Springer Nature B.V
Subjects:	Agonists Anesthesia Anesthetics, Intravenous - pharmacology Animals Arousal - physiology Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Dopamine Dopamine D1 receptors EEG GABAergic Neurons - drug effects GABAergic Neurons - metabolism General anesthesia Inhibitory postsynaptic potentials Inhibitory Postsynaptic Potentials - physiology Isoflurane Male Microinjection Modulation Neurochemistry Neurology Neurosciences Nuclei (cytology) Nucleus accumbens Nucleus Accumbens - cytology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Original Paper Photometry Propofol Propofol - pharmacology Rats Rats, Sprague-Dawley Receptors Receptors, Dopamine D1 - metabolism Sleep and wakefulness Spiny neurons Unconsciousness γ-Aminobutyric acid Nucleus accumbens General anesthesia Propofol Dopamine D1 receptor Patch-clamp
ISSN:	0364-3190, 1573-6903, 1573-6903
Online Access:	Get full text
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