Insulin-degrading enzyme higher in subjects with metabolic syndrome

Metabolic syndrome (MS) is comprised of a cluster of abnormalities in glucose, lipid, and vascular homeostasis, which is most commonly linked to abdominal obesity. MS heralds increased risk for development of diabetes and is linked to impairment in insulin signaling. Insulin-degrading enzyme (IDE) i...

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Published in:	Endocrine Vol. 71; no. 2; pp. 357 - 364
Main Authors:	Sofer, Y., Nash, Y., Osher, E., Fursht, O., Goldsmith, G., Nahary, L., Shaklai, S., Tordjman, K. M., Serebro, M., Touati, E. B., Yacobi Bach, M., Marcus, Y., Tal, B., Sack, J., Shefer, G., Margaliot, M., Landis, N., Goldiner, I., Abu Ahmad, W., Stern, N., Benhar, I., Frenkel, D.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.02.2021 Springer Nature B.V
Subjects:	Blood levels Cholesterol Diabetes Diabetes mellitus Endocrinology Enzyme-linked immunosorbent assay Enzymes High density lipoprotein Homeostasis Humanities and Social Sciences Insulin Insulysin Internal Medicine Medicine Medicine & Public Health Metabolic syndrome multidisciplinary Original Article Science Triglycerides Prediabetes Metabolic Syndrome Insulin Degradation Insulin Resistance
ISSN:	1355-008X, 1559-0100, 1559-0100
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Abstract	Metabolic syndrome (MS) is comprised of a cluster of abnormalities in glucose, lipid, and vascular homeostasis, which is most commonly linked to abdominal obesity. MS heralds increased risk for development of diabetes and is linked to impairment in insulin signaling. Insulin-degrading enzyme (IDE) is one of the mechanisms through which insulin blood levels are maintained. It has been previously suggested that controlling IDE levels could provide yet another potential therapeutic approach in diabetes. Here we aim to investigate whether changes in serum IDE levels correlate with the severity of MS. Using a highly sensitive ELISA assay of active IDE in human serum, we found a strong correlation between circulating IDE levels and circulating levels of triglycerides, insulin, and c-peptide and an inverse correlation with HDL cholesterol (HDLc). Serum IDE levels were higher in MS subjects than in control subjects. Hence, circulating IDE may serve as a tool to identify subjects with abnormal insulin metabolism, possibly those with MS that are at risk to develop diabetes.
AbstractList	Metabolic syndrome (MS) is comprised of a cluster of abnormalities in glucose, lipid, and vascular homeostasis, which is most commonly linked to abdominal obesity. MS heralds increased risk for development of diabetes and is linked to impairment in insulin signaling. Insulin-degrading enzyme (IDE) is one of the mechanisms through which insulin blood levels are maintained. It has been previously suggested that controlling IDE levels could provide yet another potential therapeutic approach in diabetes. Here we aim to investigate whether changes in serum IDE levels correlate with the severity of MS. Using a highly sensitive ELISA assay of active IDE in human serum, we found a strong correlation between circulating IDE levels and circulating levels of triglycerides, insulin, and c-peptide and an inverse correlation with HDL cholesterol (HDLc). Serum IDE levels were higher in MS subjects than in control subjects. Hence, circulating IDE may serve as a tool to identify subjects with abnormal insulin metabolism, possibly those with MS that are at risk to develop diabetes. Metabolic syndrome (MS) is comprised of a cluster of abnormalities in glucose, lipid, and vascular homeostasis, which is most commonly linked to abdominal obesity. MS heralds increased risk for development of diabetes and is linked to impairment in insulin signaling. Insulin-degrading enzyme (IDE) is one of the mechanisms through which insulin blood levels are maintained. It has been previously suggested that controlling IDE levels could provide yet another potential therapeutic approach in diabetes. Here we aim to investigate whether changes in serum IDE levels correlate with the severity of MS. Using a highly sensitive ELISA assay of active IDE in human serum, we found a strong correlation between circulating IDE levels and circulating levels of triglycerides, insulin, and c-peptide and an inverse correlation with HDL cholesterol (HDLc). Serum IDE levels were higher in MS subjects than in control subjects. Hence, circulating IDE may serve as a tool to identify subjects with abnormal insulin metabolism, possibly those with MS that are at risk to develop diabetes.Metabolic syndrome (MS) is comprised of a cluster of abnormalities in glucose, lipid, and vascular homeostasis, which is most commonly linked to abdominal obesity. MS heralds increased risk for development of diabetes and is linked to impairment in insulin signaling. Insulin-degrading enzyme (IDE) is one of the mechanisms through which insulin blood levels are maintained. It has been previously suggested that controlling IDE levels could provide yet another potential therapeutic approach in diabetes. Here we aim to investigate whether changes in serum IDE levels correlate with the severity of MS. Using a highly sensitive ELISA assay of active IDE in human serum, we found a strong correlation between circulating IDE levels and circulating levels of triglycerides, insulin, and c-peptide and an inverse correlation with HDL cholesterol (HDLc). Serum IDE levels were higher in MS subjects than in control subjects. Hence, circulating IDE may serve as a tool to identify subjects with abnormal insulin metabolism, possibly those with MS that are at risk to develop diabetes.
Author	Sofer, Y. Nahary, L. Frenkel, D. Serebro, M. Marcus, Y. Tal, B. Sack, J. Landis, N. Goldiner, I. Goldsmith, G. Stern, N. Shaklai, S. Osher, E. Nash, Y. Fursht, O. Margaliot, M. Touati, E. B. Yacobi Bach, M. Tordjman, K. M. Shefer, G. Benhar, I. Abu Ahmad, W.
Author_xml	– sequence: 1 givenname: Y. surname: Sofer fullname: Sofer, Y. email: yaelso@tlvmc.gov.il organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 2 givenname: Y. surname: Nash fullname: Nash, Y. organization: Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S Wise Faculty of Life Sciences, Tel Aviv University, Sagol School of Neuroscience, Tel Aviv University – sequence: 3 givenname: E. surname: Osher fullname: Osher, E. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 4 givenname: O. surname: Fursht fullname: Fursht, O. organization: Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S Wise Faculty of Life Sciences, Tel Aviv University – sequence: 5 givenname: G. surname: Goldsmith fullname: Goldsmith, G. organization: Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S Wise Faculty of Life Sciences, Tel Aviv University – sequence: 6 givenname: L. surname: Nahary fullname: Nahary, L. organization: Department of Molecular Microbiology and Biotechnology, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University – sequence: 7 givenname: S. surname: Shaklai fullname: Shaklai, S. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 8 givenname: K. M. surname: Tordjman fullname: Tordjman, K. M. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 9 givenname: M. surname: Serebro fullname: Serebro, M. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 10 givenname: E. B. surname: Touati fullname: Touati, E. B. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 11 givenname: M. surname: Yacobi Bach fullname: Yacobi Bach, M. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 12 givenname: Y. surname: Marcus fullname: Marcus, Y. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 13 givenname: B. surname: Tal fullname: Tal, B. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 14 givenname: J. surname: Sack fullname: Sack, J. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 15 givenname: G. surname: Shefer fullname: Shefer, G. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 16 givenname: M. surname: Margaliot fullname: Margaliot, M. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 17 givenname: N. surname: Landis fullname: Landis, N. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 18 givenname: I. surname: Goldiner fullname: Goldiner, I. organization: Laboratory Medicine, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University – sequence: 19 givenname: W. surname: Abu Ahmad fullname: Abu Ahmad, W. organization: Hebrew University-Hadassah Braun School of Public Health and Community Medicine – sequence: 20 givenname: N. surname: Stern fullname: Stern, N. organization: Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine – sequence: 21 givenname: I. surname: Benhar fullname: Benhar, I. organization: Department of Molecular Microbiology and Biotechnology, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University – sequence: 22 givenname: D. surname: Frenkel fullname: Frenkel, D. email: dfrenkel@tauex.tau.ac.il organization: Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S Wise Faculty of Life Sciences, Tel Aviv University, Sagol School of Neuroscience, Tel Aviv University
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Snippet	Metabolic syndrome (MS) is comprised of a cluster of abnormalities in glucose, lipid, and vascular homeostasis, which is most commonly linked to abdominal...
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SubjectTerms	Blood levels Cholesterol Diabetes Diabetes mellitus Endocrinology Enzyme-linked immunosorbent assay Enzymes High density lipoprotein Homeostasis Humanities and Social Sciences Insulin Insulysin Internal Medicine Medicine Medicine & Public Health Metabolic syndrome multidisciplinary Original Article Science Triglycerides
Title	Insulin-degrading enzyme higher in subjects with metabolic syndrome
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