Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response

The protein C (PC) pathway plays an important role in vascular and immune function, and acquired deficiency during sepsis is associated with increased mortality in both animal models and in clinical studies. However, the association of acquired PC deficiency with the pathophysiology of lung injury i...

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Bibliographic Details

Published in:	The Journal of pharmacology and experimental therapeutics Vol. 325; no. 1; p. 17
Main Authors:	Richardson, Mark A, Gupta, Akanksha, O'Brien, Lee A, Berg, David T, Gerlitz, Bruce, Syed, Samreen, Sharma, Ganesh R, Cramer, Martin S, Heuer, Josef G, Galbreath, Elizabeth J, Grinnell, Brian W
Format:	Journal Article
Language:	English
Published:	United States 01.04.2008
Subjects:	Angiotensin-Converting Enzyme 2 Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Gene Expression Regulation - drug effects Macrophage Inflammatory Proteins - genetics Nitric Oxide Synthase Type II - genetics Peptidyl-Dipeptidase A - drug effects Plasminogen Activator Inhibitor 1 - genetics Protein C Deficiency - drug therapy Protein C Deficiency - etiology Rats Respiratory Distress Syndrome - drug therapy Sepsis - complications Systemic Inflammatory Response Syndrome - drug therapy
ISSN:	1521-0103, 1521-0103
Online Access:	Get more information
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