Moment analysis of metabolic heterogeneity: conjugation of benzoate with glycine in rat liver studied by multiple indicator dilution technique

Metabolic zonation was assessed with the multiple indicator dilution (MID) technique in the single-pass perfused rat liver with use of moment analysis of the formed metabolite (M) data. During single-pass, retrograde rat liver perfusion with 17 Awake M benzoate, a bolus containing tracer preformed m...

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Bibliographic Details

Published in:	The Journal of pharmacology and experimental therapeutics Vol. 305; no. 1; p. 279
Main Authors:	Schwab, Andreas J, Tao, Lei, Kang, Manjinder, Meng, Lingjie, Pang, K Sandy
Format:	Journal Article
Language:	English
Published:	United States 01.04.2003
Subjects:	Animals Area Under Curve Benzoates - metabolism Carbon Radioisotopes Computer Simulation Glycine - metabolism Hepatocytes - metabolism Hippurates - metabolism Liver - cytology Liver - metabolism Male Models, Biological Rats Rats, Sprague-Dawley Tritium
ISSN:	0022-3565
Online Access:	Get more information
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