Fixed-parameter algorithms for protein similarity search under mRNA structure constraints

In the context of protein engineering, we consider the problem of computing an mRNA sequence of maximal codon-wise similarity to a given mRNA (and consequently, to a given protein) that additionally satisfies some secondary structure constraints, the so-called mRNA Structure Optimization ( MRSO) pro...

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Vydané v:	Journal of discrete algorithms (Amsterdam, Netherlands) Ročník 6; číslo 4; s. 618 - 626
Hlavní autori:	Blin, Guillaume, Fertin, Guillaume, Hermelin, Danny, Vialette, Stéphane
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Elsevier B.V 2008 Elsevier
Predmet:	Bioinformatics Computational Complexity Computer Science Data Structures and Algorithms Fixed-parameter tractability Life Sciences mRNA optimization Parameterized complexity Protein similarity Quantitative Methods Selenocysteine insertion Selenocysteine insertion mRNA optimization Protein similarity Fixed-parameter tractability Parameterized complexity parameterized complexity protein similarity fixed-parameter tractability
ISSN:	1570-8667, 1570-8675
On-line prístup:	Získať plný text
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