Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired deficiency of MHC expression. Low MHC-II expression defines tumors originating from the centroblast-rich dark zone of the g...

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Bibliographic Details

Published in:	Cancer discovery Vol. 9; no. 4; p. 546
Main Authors:	Ennishi, Daisuke, Takata, Katsuyoshi, Béguelin, Wendy, Duns, Gerben, Mottok, Anja, Farinha, Pedro, Bashashati, Ali, Saberi, Saeed, Boyle, Merrill, Meissner, Barbara, Ben-Neriah, Susana, Woolcock, Bruce W, Telenius, Adèle, Lai, Daniel, Teater, Matt, Kridel, Robert, Savage, Kerry J, Sehn, Laurie H, Morin, Ryan D, Marra, Marco A, Shah, Sohrab P, Connors, Joseph M, Gascoyne, Randy D, Scott, David W, Melnick, Ari M, Steidl, Christian
Format:	Journal Article
Language:	English
Published:	United States 01.04.2019
Subjects:	Animals Cell Line, Tumor Enhancer of Zeste Homolog 2 Protein - genetics Gene Expression Regulation, Neoplastic - genetics Humans Mice Prognosis
ISSN:	2159-8290, 2159-8290
Online Access:	Get more information
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