Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired deficiency of MHC expression. Low MHC-II expression defines tumors originating from the centroblast-rich dark zone of the g...

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Veröffentlicht in:	Cancer discovery Jg. 9; H. 4; S. 546
Hauptverfasser:	Ennishi, Daisuke, Takata, Katsuyoshi, Béguelin, Wendy, Duns, Gerben, Mottok, Anja, Farinha, Pedro, Bashashati, Ali, Saberi, Saeed, Boyle, Merrill, Meissner, Barbara, Ben-Neriah, Susana, Woolcock, Bruce W, Telenius, Adèle, Lai, Daniel, Teater, Matt, Kridel, Robert, Savage, Kerry J, Sehn, Laurie H, Morin, Ryan D, Marra, Marco A, Shah, Sohrab P, Connors, Joseph M, Gascoyne, Randy D, Scott, David W, Melnick, Ari M, Steidl, Christian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2019
Schlagworte:	Animals Cell Line, Tumor Enhancer of Zeste Homolog 2 Protein - genetics Gene Expression Regulation, Neoplastic - genetics Humans Mice Prognosis
ISSN:	2159-8290, 2159-8290
Online-Zugang:	Weitere Angaben
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