The PIN1–p38–CtIP signalling axis protects stalled replication forks from deleterious degradation

Abstract Human CtIP plays a critical role in homologous recombination (HR) by promoting the resection of DNA double-strand breaks. Moreover, CtIP maintains genome stability through protecting stalled replication forks from nucleolytic degradation. However, the upstream signalling mechanisms governin...

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Veröffentlicht in:	Nucleic acids research Jg. 53; H. 7
Hauptverfasser:	Vivalda, Francesca, Gatti, Marco, Manfredi, Letizia, Dogan, Hülya, Porro, Antonio, Collotta, Giulio, Ceppi, Ilaria, von Aesch, Christine, van Ackeren, Vanessa, Wild, Sebastian, Steger, Martin, Canovas, Begoña, Cubillos-Rojas, Monica, Riera, Antoni, Cejka, Petr, Nebreda, Angel R, Dibitetto, Diego, Rottenberg, Sven, Sartori, Alessandro A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 10.04.2025
Schlagworte:	BRCA1 Protein - genetics Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor DNA Breaks, Double-Stranded DNA Replication Endodeoxyribonucleases Genome Integrity, Repair and Humans Mitogen-Activated Protein Kinase 14 - genetics Mitogen-Activated Protein Kinase 14 - metabolism NIMA-Interacting Peptidylprolyl Isomerase - genetics NIMA-Interacting Peptidylprolyl Isomerase - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Signal Transduction
ISSN:	0305-1048, 1362-4962, 1362-4962
Online-Zugang:	Volltext
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