Protective effect of Globularia alypum leaves against deltamethrin-induced nephrotoxicity in rats and determination of its bioactive compounds using high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole–time-of-flight mass spectrometry

•RP-HPLC-DAD-ESI-QTOF-MS/MS analysis of Globularia alypum extract was performed.•Thirty-nine compounds were identified and quantified.•Protective effect of G. alypum against deltamethrin induced nephrotoxicity was determined.•G. alypum reduces the DNA damage and fibrosis in the kidney. This study wa...

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Veröffentlicht in:	Journal of functional foods Jg. 32; S. 139 - 148
Hauptverfasser:	Feriani, Anouar, del Mar Contreras, María, Talhaoui, Nassima, Gómez-Caravaca, Ana María, Taamalli, Amani, Segura-Carretero, Antonio, Ghazouani, Lakhdar, El Feki, Abdelfatteh, Allagui, Mohamed Salah
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Elsevier Ltd 01.05.2017
Schlagworte:	Antioxidant antioxidants bioactive compounds chronic exposure creatinine Deltamethrin enzyme activity fibrosis Globularia alypum hemorrhage high performance liquid chromatography histopathology HPLC-DAD-ESI-QTOF-MS ionization leaf extracts leaves mass spectrometry necrosis Nephrotoxicity protective effect proximal tubules rats urea uric acid Globularia alypum HPLC-DAD-ESI-QTOF-MS Antioxidant Deltamethrin Nephrotoxicity
ISSN:	1756-4646, 2214-9414
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Abstract	•RP-HPLC-DAD-ESI-QTOF-MS/MS analysis of Globularia alypum extract was performed.•Thirty-nine compounds were identified and quantified.•Protective effect of G. alypum against deltamethrin induced nephrotoxicity was determined.•G. alypum reduces the DNA damage and fibrosis in the kidney. This study was designed to investigate the protective effects of Globularia alypum leaves extract (GE) against the nephrotoxicity provoked by a chronic exposure to deltamethrin (DLM) in rats. High-performance liquid chromatography coupled with electrospray ionization tandem quadrupole–time-of-flight mass spectrometry (HPLC-DAD-ESI-QTOF-MS) analysis revealed the presence of thirty-nine compounds among them globularin was the major compound (9444mg/100g of dry matter). Results showed that DLM administration altered the renal functions. Whereas, GE treatment restored the increased plasma creatinine, urea and uric acid levels, reduced the elevated MDA and PC levels, significantly normalized the antioxidant enzyme activities. In addition, histopathologic examination confirmed the deltamethrin damage to the renal tissue and revealed renal connective tissue fibrosis and severe necrosis of the proximal tubules with haemorrhage, which was corrected by GE treatment. Therefore, it was speculated that GE presented a protective effects against deltamethrin induced nephrotoxicity through the action of its bioactive compounds.
AbstractList	•RP-HPLC-DAD-ESI-QTOF-MS/MS analysis of Globularia alypum extract was performed.•Thirty-nine compounds were identified and quantified.•Protective effect of G. alypum against deltamethrin induced nephrotoxicity was determined.•G. alypum reduces the DNA damage and fibrosis in the kidney. This study was designed to investigate the protective effects of Globularia alypum leaves extract (GE) against the nephrotoxicity provoked by a chronic exposure to deltamethrin (DLM) in rats. High-performance liquid chromatography coupled with electrospray ionization tandem quadrupole–time-of-flight mass spectrometry (HPLC-DAD-ESI-QTOF-MS) analysis revealed the presence of thirty-nine compounds among them globularin was the major compound (9444mg/100g of dry matter). Results showed that DLM administration altered the renal functions. Whereas, GE treatment restored the increased plasma creatinine, urea and uric acid levels, reduced the elevated MDA and PC levels, significantly normalized the antioxidant enzyme activities. In addition, histopathologic examination confirmed the deltamethrin damage to the renal tissue and revealed renal connective tissue fibrosis and severe necrosis of the proximal tubules with haemorrhage, which was corrected by GE treatment. Therefore, it was speculated that GE presented a protective effects against deltamethrin induced nephrotoxicity through the action of its bioactive compounds. This study was designed to investigate the protective effects of Globularia alypum leaves extract (GE) against the nephrotoxicity provoked by a chronic exposure to deltamethrin (DLM) in rats. High-performance liquid chromatography coupled with electrospray ionization tandem quadrupole–time-of-flight mass spectrometry (HPLC-DAD-ESI-QTOF-MS) analysis revealed the presence of thirty-nine compounds among them globularin was the major compound (9444mg/100g of dry matter). Results showed that DLM administration altered the renal functions. Whereas, GE treatment restored the increased plasma creatinine, urea and uric acid levels, reduced the elevated MDA and PC levels, significantly normalized the antioxidant enzyme activities. In addition, histopathologic examination confirmed the deltamethrin damage to the renal tissue and revealed renal connective tissue fibrosis and severe necrosis of the proximal tubules with haemorrhage, which was corrected by GE treatment. Therefore, it was speculated that GE presented a protective effects against deltamethrin induced nephrotoxicity through the action of its bioactive compounds.
Author	Segura-Carretero, Antonio El Feki, Abdelfatteh Talhaoui, Nassima Taamalli, Amani Ghazouani, Lakhdar Feriani, Anouar Gómez-Caravaca, Ana María Allagui, Mohamed Salah del Mar Contreras, María
Author_xml	– sequence: 1 givenname: Anouar surname: Feriani fullname: Feriani, Anouar email: ferianianwer@yahoo.fr organization: Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia – sequence: 2 givenname: María surname: del Mar Contreras fullname: del Mar Contreras, María email: mar.contreras.gamez@gmail.com organization: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avenida Fuentenueva s/n, 18071 Granada, Spain – sequence: 3 givenname: Nassima surname: Talhaoui fullname: Talhaoui, Nassima email: nassima.talhaoui@gmail.com organization: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avenida Fuentenueva s/n, 18071 Granada, Spain – sequence: 4 givenname: Ana María surname: Gómez-Caravaca fullname: Gómez-Caravaca, Ana María email: anagomez@ugr.es organization: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avenida Fuentenueva s/n, 18071 Granada, Spain – sequence: 5 givenname: Amani surname: Taamalli fullname: Taamalli, Amani email: taamalli_ameni@yahoo.fr organization: Laboratory of Olive Biotechnology, Center of Biotechnology of Borj-Cédria, BP. 901, 2050 Hammam-Lif, Tunisia – sequence: 6 givenname: Antonio surname: Segura-Carretero fullname: Segura-Carretero, Antonio email: ansegura@ugr.es organization: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avenida Fuentenueva s/n, 18071 Granada, Spain – sequence: 7 givenname: Lakhdar surname: Ghazouani fullname: Ghazouani, Lakhdar email: lakhdar.ghazouani@gmail.com organization: Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia – sequence: 8 givenname: Abdelfatteh surname: El Feki fullname: El Feki, Abdelfatteh email: abdelfattah.elfeki@fss.rnu.tn organization: Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia – sequence: 9 givenname: Mohamed Salah surname: Allagui fullname: Allagui, Mohamed Salah email: amsallagui@yahoo.fr organization: Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia
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Snippet	•RP-HPLC-DAD-ESI-QTOF-MS/MS analysis of Globularia alypum extract was performed.•Thirty-nine compounds were identified and quantified.•Protective effect of G.... This study was designed to investigate the protective effects of Globularia alypum leaves extract (GE) against the nephrotoxicity provoked by a chronic...
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SubjectTerms	Antioxidant antioxidants bioactive compounds chronic exposure creatinine Deltamethrin enzyme activity fibrosis Globularia alypum hemorrhage high performance liquid chromatography histopathology HPLC-DAD-ESI-QTOF-MS ionization leaf extracts leaves mass spectrometry necrosis Nephrotoxicity protective effect proximal tubules rats urea uric acid
Title	Protective effect of Globularia alypum leaves against deltamethrin-induced nephrotoxicity in rats and determination of its bioactive compounds using high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole–time-of-flight mass spectrometry
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