Brown locusts, Locustana pardalina, host fluconazole-resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains
Abstract The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to Candidozyma auris have...
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| Vydáno v: | Medical mycology (Oxford) Ročník 63; číslo 8 |
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| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
Oxford University Press
05.08.2025
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| ISSN: | 1369-3786, 1460-2709, 1460-2709 |
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| Abstract | Abstract
The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to Candidozyma auris have been repeatedly observed associated with various insects. This prompted us to investigate a thermophilic insect, Locustana pardalina, as a possible host for C. auris. Here, we report the isolation and identification of three C. auris strains from the gut of L. pardalina as well as the phenotypic characterisation of one of these isolates. Interestingly, the isolate was able to survive at 50°C and grew at 15% NaCl. In addition, it was susceptible to the tested disinfectants and antifungals, except fluconazole. Genome sequencing and single-nucleotide polymorphism analyses placed the isolate in Clade III, which is common in South African hospitals. This highlights the potential role of thermotolerant insects in the evolution and dissemination of emerging pathogenic yeasts.
Lay Summary
The study investigates the presence of the pathogenic yeast, Candidozyma auris, in brown locusts. The characterised strain was related to hospital strains previously found in South Africa and was resistant to fluconazole. This highlights the potential role of insects in spreading this pathogen. |
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| AbstractList | Abstract
The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to Candidozyma auris have been repeatedly observed associated with various insects. This prompted us to investigate a thermophilic insect, Locustana pardalina, as a possible host for C. auris. Here, we report the isolation and identification of three C. auris strains from the gut of L. pardalina as well as the phenotypic characterisation of one of these isolates. Interestingly, the isolate was able to survive at 50°C and grew at 15% NaCl. In addition, it was susceptible to the tested disinfectants and antifungals, except fluconazole. Genome sequencing and single-nucleotide polymorphism analyses placed the isolate in Clade III, which is common in South African hospitals. This highlights the potential role of thermotolerant insects in the evolution and dissemination of emerging pathogenic yeasts.
Lay Summary
The study investigates the presence of the pathogenic yeast, Candidozyma auris, in brown locusts. The characterised strain was related to hospital strains previously found in South Africa and was resistant to fluconazole. This highlights the potential role of insects in spreading this pathogen. The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to Candidozyma auris have been repeatedly observed associated with various insects. This prompted us to investigate a thermophilic insect, Locustana pardalina, as a possible host for C. auris. Here, we report the isolation and identification of three C. auris strains from the gut of L. pardalina as well as the phenotypic characterisation of one of these isolates. Interestingly, the isolate was able to survive at 50°C and grew at 15% NaCl. In addition, it was susceptible to the tested disinfectants and antifungals, except fluconazole. Genome sequencing and single-nucleotide polymorphism analyses placed the isolate in Clade III, which is common in South African hospitals. This highlights the potential role of thermotolerant insects in the evolution and dissemination of emerging pathogenic yeasts. The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to Candidozyma auris have been repeatedly observed associated with various insects. This prompted us to investigate a thermophilic insect, Locustana pardalina, as a possible host for C. auris. Here, we report the isolation and identification of three C. auris strains from the gut of L. pardalina as well as the phenotypic characterisation of one of these isolates. Interestingly, the isolate was able to survive at 50°C and grew at 15% NaCl. In addition, it was susceptible to the tested disinfectants and antifungals, except fluconazole. Genome sequencing and single-nucleotide polymorphism analyses placed the isolate in Clade III, which is common in South African hospitals. This highlights the potential role of thermotolerant insects in the evolution and dissemination of emerging pathogenic yeasts.The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to Candidozyma auris have been repeatedly observed associated with various insects. This prompted us to investigate a thermophilic insect, Locustana pardalina, as a possible host for C. auris. Here, we report the isolation and identification of three C. auris strains from the gut of L. pardalina as well as the phenotypic characterisation of one of these isolates. Interestingly, the isolate was able to survive at 50°C and grew at 15% NaCl. In addition, it was susceptible to the tested disinfectants and antifungals, except fluconazole. Genome sequencing and single-nucleotide polymorphism analyses placed the isolate in Clade III, which is common in South African hospitals. This highlights the potential role of thermotolerant insects in the evolution and dissemination of emerging pathogenic yeasts. |
| Author | Swart, Vaughn Ogundeji, Adepemi Baker, Tyla Albertyn, Jacobus Bolsenbroek, Armand Beneke, Carel Cason, Errol D Featherston, Jonathan Musoke, Jolly Pohl, Carolina Ismail, Arshad Sebolai, Olihile Bello-Akinosho, Maryam |
| Author_xml | – sequence: 1 givenname: Adepemi surname: Ogundeji fullname: Ogundeji, Adepemi – sequence: 2 givenname: Maryam surname: Bello-Akinosho fullname: Bello-Akinosho, Maryam – sequence: 3 givenname: Vaughn surname: Swart fullname: Swart, Vaughn – sequence: 4 givenname: Jonathan surname: Featherston fullname: Featherston, Jonathan – sequence: 5 givenname: Errol D surname: Cason fullname: Cason, Errol D – sequence: 6 givenname: Armand surname: Bolsenbroek fullname: Bolsenbroek, Armand – sequence: 7 givenname: Carel surname: Beneke fullname: Beneke, Carel – sequence: 8 givenname: Jolly surname: Musoke fullname: Musoke, Jolly – sequence: 9 givenname: Tyla surname: Baker fullname: Baker, Tyla – sequence: 10 givenname: Arshad orcidid: 0000-0003-4672-5915 surname: Ismail fullname: Ismail, Arshad – sequence: 11 givenname: Olihile orcidid: 0000-0002-0182-1084 surname: Sebolai fullname: Sebolai, Olihile – sequence: 12 givenname: Jacobus surname: Albertyn fullname: Albertyn, Jacobus – sequence: 13 givenname: Carolina orcidid: 0000-0001-6928-5663 surname: Pohl fullname: Pohl, Carolina email: PohlCH@ufs.ac.za |
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| Keywords | fluconazole stress tolerance environmental niche disinfectants ( ) One Health Locustana pardalina Candidozyma (Candida) auris |
| Language | English |
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The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a... The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of... |
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| SubjectTerms | Animals Antifungal Agents - pharmacology Candida auris - classification Candida auris - drug effects Candida auris - genetics Candida auris - isolation & purification Drug Resistance, Fungal Fluconazole - pharmacology Genome, Fungal Grasshoppers - microbiology Humans Microbial Sensitivity Tests Original Phylogeny Polymorphism, Single Nucleotide Whole Genome Sequencing |
| Title | Brown locusts, Locustana pardalina, host fluconazole-resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains |
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