Antidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds

[Display omitted] •Proteolytically digested γ-conglutin from lupin possesses anti-diabetic properties.•γ-conglutin peptides promote glucose uptake and glycogen synthesis in human muscle cells.•γ-conglutin peptides activate AKT/mTOR/p70S6K signalling and promote protein synthesis.•γ-conglutin peptide...

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Bibliographic Details
Published in:	Journal of functional foods Vol. 87; p. 104786
Main Authors:	Tapadia, Mrunmai, Johnson, Stuart, Utikar, Ranjeet, Newsholme, Philip, Carlessi, Rodrigo
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01.12.2021
Subjects:	Antidiabetic DPP4 inhibitor gastrointestinal system glucose glycogen half life healthy diet humans insulin Insulin mimetic insulin secretion Lupin seeds Lupinus markets myotubes oral administration protein synthesis proteolysis secretin skeletal muscle value added γ-conglutin Lupin seeds OPA 2-NBDG eIF4e S6 DH KRBB DPP4 inhibitor Gαq/PLC/PKC IRS-1 Antidiabetic HSMM MTT γ-conglutin OPP AUC DPP4 BSA PI3K FBS mTOR ESI PBS pNPG GLP-1 MS IR GS ECL GIP RP-HPLC SDS-PAGE 70S6K GSK3β Insulin mimetic MWCO ERK1/2 TSC1/2 4EBPI PI PDK-1 mTORC2 GAPDH ELISA
ISSN:	1756-4646, 2214-9414
Online Access:	Get full text
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