Toward optimizing diversifying base editors for high-throughput mutational scanning studies

Abstract Base editors, including diversifying base editors that create C>N mutations, are potent tools for systematically installing point mutations in mammalian genomes and studying their effect on cellular function. Numerous base editor options are available for such studies, but little informa...

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Vydáno v:	Nucleic acids research Ročník 53; číslo 12
Hlavní autoři:	Schwartz, Carley I, Abell, Nathan S, Li, Amy, Aradhana, Tycko, Josh, Truong, Alisa, Montgomery, Stephen B, Hess, Gaelen T
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Oxford University Press 20.06.2025
Témata:	AICDA (Activation-Induced Cytidine Deaminase) CRISPR-Associated Protein 9 - genetics CRISPR-Associated Protein 9 - metabolism CRISPR-Cas Systems Cytidine Deaminase - genetics Cytidine Deaminase - metabolism DNA Mutational Analysis - methods Gene Editing - methods HEK293 Cells Humans Methods Mutation Point Mutation RNA, Guide, CRISPR-Cas Systems - genetics
ISSN:	0305-1048, 1362-4962, 1362-4962
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