Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials

Fragile X syndrome (FXS), the most common cause of inherited intellectual disability and autistic spectrum disorder, is typically caused by transcriptional silencing of the X-linked FMR1 gene. Work in animal models has described altered synaptic plasticity, a result of the up-regulation of metabotro...

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Vydané v:	Science translational medicine Ročník 8; číslo 321; s. 321ra5
Hlavní autori:	Berry-Kravis, Elizabeth, Des Portes, Vincent, Hagerman, Randi, Jacquemont, Sébastien, Charles, Perrine, Visootsak, Jeannie, Brinkman, Marc, Rerat, Karin, Koumaras, Barbara, Zhu, Liansheng, Barth, Gottfried Maria, Jaecklin, Thomas, Apostol, George, von Raison, Florian
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 13.01.2016
Predmet:	Adolescent Adult Age Factors Behavior Cognition Demography DNA Methylation - drug effects Double-Blind Method Female Fragile X Syndrome - drug therapy Fragile X Syndrome - genetics Humans Indoles - pharmacology Indoles - therapeutic use Least-Squares Analysis Male Placebos Treatment Outcome
ISSN:	1946-6242
On-line prístup:	Zistit podrobnosti o prístupe
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