Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials

Fragile X syndrome (FXS), the most common cause of inherited intellectual disability and autistic spectrum disorder, is typically caused by transcriptional silencing of the X-linked FMR1 gene. Work in animal models has described altered synaptic plasticity, a result of the up-regulation of metabotro...

Full description

Saved in:

Bibliographic Details
Published in:	Science translational medicine Vol. 8; no. 321; p. 321ra5
Main Authors:	Berry-Kravis, Elizabeth, Des Portes, Vincent, Hagerman, Randi, Jacquemont, Sébastien, Charles, Perrine, Visootsak, Jeannie, Brinkman, Marc, Rerat, Karin, Koumaras, Barbara, Zhu, Liansheng, Barth, Gottfried Maria, Jaecklin, Thomas, Apostol, George, von Raison, Florian
Format:	Journal Article
Language:	English
Published:	United States 13.01.2016
Subjects:	Adolescent Adult Age Factors Behavior Cognition Demography DNA Methylation - drug effects Double-Blind Method Female Fragile X Syndrome - drug therapy Fragile X Syndrome - genetics Humans Indoles - pharmacology Indoles - therapeutic use Least-Squares Analysis Male Placebos Treatment Outcome
ISSN:	1946-6242
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!