Activating Effect of 3‐Benzylidene Oxindoles on AMPK: From Computer Simulation to High‐Content Screening

AMP‐activated protein kinase (AMPK) is currently the subject of intensive study and active discussions. AMPK performs its functions both at the cellular level, providing the switch between energy‐consuming and energy‐producing processes, and at the whole body level, particularly, regulating certain...

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Vydané v:	ChemMedChem Ročník 15; číslo 24; s. 2521 - 2529
Hlavní autori:	Novikova, Daria S., Grigoreva, Tatyana A., Ivanov, Gleb S., Melino, Gerry, Barlev, Nickolai A., Tribulovich, Vyacheslav G.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	WEINHEIM Wiley 15.12.2020 Wiley Subscription Services, Inc
Predmet:	AMP AMPK Binding sites Chemistry, Medicinal Computer simulation Domains Fluorescence resonance energy transfer FRET high-content screening Kinases Life Sciences & Biomedicine molecular modeling Pharmacology & Pharmacy Protein kinase Science & Technology Screening structure-activity relationships TARGET PROTEIN-KINASE PREVENTION high-content screening AUTOINHIBITION structure-activity relationships METABOLISM molecular modeling STRUCTURAL BASIS AMPK FRET INHIBITORS DERIVATIVES BINDING
ISSN:	1860-7179, 1860-7187, 1860-7187
On-line prístup:	Získať plný text
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