Discovery of an Ultra‐rapid and Sensitive Lysosomal Fluorescence Lipophagy Process

Non‐invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases. However, many fluorescent dyes developed so far to target lysosomes cannot be used to monitor these processes due to the high concentrations...

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Veröffentlicht in:	Angewandte Chemie International Edition Jg. 61; H. 11; S. e202116439 - n/a
Hauptverfasser:	Zhang, Hong, Shi, Lei, Li, Kun, Liu, Xin, Won, Miae, Liu, Yan‐Zhao, Choe, Youmi, Liu, Xin‐Yao, Liu, Yan‐Hong, Chen, Shan‐Yong, Yu, Kang‐Kang, Kim, Jong Seung, Yu, Xiao‐Qi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	WEINHEIM Wiley 07.03.2022 Wiley Subscription Services, Inc
Ausgabe:	International ed. in English
Schlagworte:	Autophagy Chemistry Chemistry, Multidisciplinary Dyes Fluorescence Fluorescent dyes Fluorescent indicators Large Stokes Shift Lipophagy Low concentrations Lysosomes Near-Infrared Organelles Physical Sciences Probes Science & Technology CELLS ADIPOCYTES DYES Lipophagy Large Stokes Shift Lysosomes AUTOPHAGY DIFFERENTIATION MODEL Near-Infrared PROBES
ISSN:	1433-7851, 1521-3773, 1521-3773
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Abstract	Non‐invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases. However, many fluorescent dyes developed so far to target lysosomes cannot be used to monitor these processes due to the high concentrations required for imaging, long cell penetration times, and non‐ideal photostability. In this regard, we synthesized three lysosomal targeting probes with large Stokes shifts, good stability, and high brightness. The Q‐P‐ARh dye, developed by us for the first time, can stain lysosomes at ultra‐low concentrations (1.0 nM) without affecting the physiological functions of the lysosomes. More importantly, its excellent anti‐interference ability and ultrafast lysosomal staining ability (within 1.0 min) clearly monitored the entire dynamic process of lipophagy. Ultimately, this method can greatly contribute to the study of autophagy pathways. This novel fluorescence platform shows great promise for the development of biological probes for application in pathological environments. A series of brand‐new large Stokes shift and highly stable fluorescent dyes were constructed. In particular, the Q‐P‐ARh fluorescent dye as a near‐infrared emission lysosomal‐specific probe with ultra‐low concentration and ultra‐fast staining characteristics for the complete lipophagy process imaging is presented.
AbstractList	Non‐invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases. However, many fluorescent dyes developed so far to target lysosomes cannot be used to monitor these processes due to the high concentrations required for imaging, long cell penetration times, and non‐ideal photostability. In this regard, we synthesized three lysosomal targeting probes with large Stokes shifts, good stability, and high brightness. The Q‐P‐ARh dye, developed by us for the first time, can stain lysosomes at ultra‐low concentrations (1.0 nM) without affecting the physiological functions of the lysosomes. More importantly, its excellent anti‐interference ability and ultrafast lysosomal staining ability (within 1.0 min) clearly monitored the entire dynamic process of lipophagy. Ultimately, this method can greatly contribute to the study of autophagy pathways. This novel fluorescence platform shows great promise for the development of biological probes for application in pathological environments. A series of brand‐new large Stokes shift and highly stable fluorescent dyes were constructed. In particular, the Q‐P‐ARh fluorescent dye as a near‐infrared emission lysosomal‐specific probe with ultra‐low concentration and ultra‐fast staining characteristics for the complete lipophagy process imaging is presented. Non-invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases. However, many fluorescent dyes developed so far to target lysosomes cannot be used to monitor these processes due to the high concentrations required for imaging, long cell penetration times, and non-ideal photostability. In this regard, we synthesized three lysosomal targeting probes with large Stokes shifts, good stability, and high brightness. The Q-P-ARh dye, developed by us for the first time, can stain lysosomes at ultra-low concentrations (1.0 nM) without affecting the physiological functions of the lysosomes. More importantly, its excellent anti-interference ability and ultrafast lysosomal staining ability (within 1.0 min) clearly monitored the entire dynamic process of lipophagy. Ultimately, this method can greatly contribute to the study of autophagy pathways. This novel fluorescence platform shows great promise for the development of biological probes for application in pathological environments. Non-invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases. However, many fluorescent dyes developed so far to target lysosomes cannot be used to monitor these processes due to the high concentrations required for imaging, long cell penetration times, and non-ideal photostability. In this regard, we synthesized three lysosomal targeting probes with large Stokes shifts, good stability, and high brightness. The Q-P-ARh dye, developed by us for the first time, can stain lysosomes at ultra-low concentrations (1.0 nM) without affecting the physiological functions of the lysosomes. More importantly, its excellent anti-interference ability and ultrafast lysosomal staining ability (within 1.0 min) clearly monitored the entire dynamic process of lipophagy. Ultimately, this method can greatly contribute to the study of autophagy pathways. This novel fluorescence platform shows great promise for the development of biological probes for application in pathological environments.Non-invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases. However, many fluorescent dyes developed so far to target lysosomes cannot be used to monitor these processes due to the high concentrations required for imaging, long cell penetration times, and non-ideal photostability. In this regard, we synthesized three lysosomal targeting probes with large Stokes shifts, good stability, and high brightness. The Q-P-ARh dye, developed by us for the first time, can stain lysosomes at ultra-low concentrations (1.0 nM) without affecting the physiological functions of the lysosomes. More importantly, its excellent anti-interference ability and ultrafast lysosomal staining ability (within 1.0 min) clearly monitored the entire dynamic process of lipophagy. Ultimately, this method can greatly contribute to the study of autophagy pathways. This novel fluorescence platform shows great promise for the development of biological probes for application in pathological environments. Non‐invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases. However, many fluorescent dyes developed so far to target lysosomes cannot be used to monitor these processes due to the high concentrations required for imaging, long cell penetration times, and non‐ideal photostability. In this regard, we synthesized three lysosomal targeting probes with large Stokes shifts, good stability, and high brightness. The Q‐P‐ARh dye, developed by us for the first time, can stain lysosomes at ultra‐low concentrations (1.0 nM) without affecting the physiological functions of the lysosomes. More importantly, its excellent anti‐interference ability and ultrafast lysosomal staining ability (within 1.0 min) clearly monitored the entire dynamic process of lipophagy. Ultimately, this method can greatly contribute to the study of autophagy pathways. This novel fluorescence platform shows great promise for the development of biological probes for application in pathological environments.
ArticleNumber	202116439
Author	Won, Miae Zhang, Hong Li, Kun Kim, Jong Seung Liu, Yan‐Hong Choe, Youmi Yu, Xiao‐Qi Liu, Yan‐Zhao Shi, Lei Chen, Shan‐Yong Liu, Xin Liu, Xin‐Yao Yu, Kang‐Kang
Author_xml	– sequence: 1 givenname: Hong surname: Zhang fullname: Zhang, Hong organization: Sichuan University – sequence: 2 givenname: Lei surname: Shi fullname: Shi, Lei organization: Sichuan University – sequence: 3 givenname: Kun orcidid: 0000-0002-8788-1036 surname: Li fullname: Li, Kun email: kli@scu.edu.cn organization: Sichuan University – sequence: 4 givenname: Xin surname: Liu fullname: Liu, Xin organization: Sichuan University – sequence: 5 givenname: Miae orcidid: 0000-0002-1656-6362 surname: Won fullname: Won, Miae organization: Korea University – sequence: 6 givenname: Yan‐Zhao surname: Liu fullname: Liu, Yan‐Zhao organization: Sichuan University – sequence: 7 givenname: Youmi surname: Choe fullname: Choe, Youmi organization: Korea University – sequence: 8 givenname: Xin‐Yao surname: Liu fullname: Liu, Xin‐Yao organization: Sichuan University – sequence: 9 givenname: Yan‐Hong surname: Liu fullname: Liu, Yan‐Hong organization: Sichuan University – sequence: 10 givenname: Shan‐Yong surname: Chen fullname: Chen, Shan‐Yong organization: Sichuan University – sequence: 11 givenname: Kang‐Kang surname: Yu fullname: Yu, Kang‐Kang organization: Sichuan University – sequence: 12 givenname: Jong Seung orcidid: 0000-0003-3477-1172 surname: Kim fullname: Kim, Jong Seung email: jongskim@korea.ac.kr organization: Korea University – sequence: 13 givenname: Xiao‐Qi orcidid: 0000-0003-1719-6137 surname: Yu fullname: Yu, Xiao‐Qi email: xqyu@scu.edu.cn organization: Sichuan University
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Keywords	CELLS ADIPOCYTES DYES Lipophagy Large Stokes Shift Lysosomes AUTOPHAGY DIFFERENTIATION MODEL Near-Infrared PROBES
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Snippet	Non‐invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases.... Non-invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study of lysosomal function and related diseases....
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SubjectTerms	Autophagy Chemistry Chemistry, Multidisciplinary Dyes Fluorescence Fluorescent dyes Fluorescent indicators Large Stokes Shift Lipophagy Low concentrations Lysosomes Near-Infrared Organelles Physical Sciences Probes Science & Technology
Title	Discovery of an Ultra‐rapid and Sensitive Lysosomal Fluorescence Lipophagy Process
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