Rational Design of Polymethine Dyes with NIR‐II Emission and High Photothermal Conversion Efficiency for Multimodal‐Imaging‐Guided Photo‐Immunotherapy

Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging a...

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Veröffentlicht in:	Advanced materials (Weinheim) Jg. 35; H. 12; S. e2210179 - n/a
Hauptverfasser:	Ran, Xiao‐Yun, Chen, Ping, Liu, Yan‐Zhao, Shi, Lei, Chen, Xue, Liu, Yan‐Hong, Zhang, Hong, Zhang, Li‐Na, Li, Kun, Yu, Xiao‐Qi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany Wiley Subscription Services, Inc 01.03.2023
Schlagworte:	Breast Neoplasms Coloring Agents Diagnosis Emission Female Fluorescence Humans Hyperthermia Immunotherapy Infrared windows Materials science Medical imaging Nanoparticles Nanoparticles - therapeutic use Near infrared radiation Neoplasms - diagnostic imaging Neoplasms - therapy Organic chemistry photoacoustic imaging Photoacoustic Techniques - methods photodynamic therapy Phototherapy - methods Photothermal conversion photothermal therapy polymethine dyes second near‐infrared emission Theranostic Nanomedicine - methods polymethine dyes second near-infrared emission photoacoustic imaging photodynamic therapy immunotherapy photothermal therapy
ISSN:	0935-9648, 1521-4095, 1521-4095
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Abstract	Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging ability and photothermal conversion efficiency (PCE) of phototheranostic agents. Hence, how to balance the competitive radiative and nonradiative processes of phototheranostic agents is the key factor to evaluate the phototheranostic effect. Herein, molecules named ICRs with high photostaibility are rationally designed, exhibiting fluorescence emission in the second near‐infrared window (NIR‐II, 1000–1700 nm) and high PCE, which are related to the strong donor–acceptor (D–A) interaction and high reorganization energy Noteworthily, ICR‐Qu with stronger D–A interaction and a large‐sized conjugated unit encapsulated in nanoparticles exhibits high PCE (81.1%). In addition, ICR‐QuNPs are used for fluorescence imaging (FLI), photoacoustic imaging (PAI), and photothermal imaging (PTI) to guide deep‐tissue photonic hyperthermia, achieving precise removal and inhibition of breast cancer. Furthermore, combined with α‐PD‐1, ICR‐QuNPs show huge potential to be a facile and efficient tool for photo‐immunotherapy. More importantly, this study not only reports an “all‐in‐one” polymethine‐based phototheranostic agent, but also sheds light on the exploration of versatile organic molecules for future practical applications. Polymethine dyes with second near‐infrared emission and photoacoustic imaging capability are synthesized by the electronic‐donor group regulation strategy, which demonstrates high photothermal conversion efficiency (PCE = 81.1%) as an antitumor stategy in vivo and in vitro under the multimodal imaging guidance; theoretical calculation reveals the structure regulation mechanism for the polymethine‐based phototheranostic agent to achieve an excellent PCE.
AbstractList	Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging ability and photothermal conversion efficiency (PCE) of phototheranostic agents. Hence, how to balance the competitive radiative and nonradiative processes of phototheranostic agents is the key factor to evaluate the phototheranostic effect. Herein, molecules named ICRs with high photostaibility are rationally designed, exhibiting fluorescence emission in the second near-infrared window (NIR-II, 1000-1700 nm) and high PCE, which are related to the strong donor-acceptor (D-A) interaction and high reorganization energy Noteworthily, ICR-Qu with stronger D-A interaction and a large-sized conjugated unit encapsulated in nanoparticles exhibits high PCE (81.1%). In addition, ICR-QuNPs are used for fluorescence imaging (FLI), photoacoustic imaging (PAI), and photothermal imaging (PTI) to guide deep-tissue photonic hyperthermia, achieving precise removal and inhibition of breast cancer. Furthermore, combined with α-PD-1, ICR-QuNPs show huge potential to be a facile and efficient tool for photo-immunotherapy. More importantly, this study not only reports an "all-in-one" polymethine-based phototheranostic agent, but also sheds light on the exploration of versatile organic molecules for future practical applications. Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging ability and photothermal conversion efficiency (PCE) of phototheranostic agents. Hence, how to balance the competitive radiative and nonradiative processes of phototheranostic agents is the key factor to evaluate the phototheranostic effect. Herein, molecules named ICRs with high photostaibility are rationally designed, exhibiting fluorescence emission in the second near-infrared window (NIR-II, 1000-1700 nm) and high PCE, which are related to the strong donor-acceptor (D-A) interaction and high reorganization energy Noteworthily, ICR-Qu with stronger D-A interaction and a large-sized conjugated unit encapsulated in nanoparticles exhibits high PCE (81.1%). In addition, ICR-QuNPs are used for fluorescence imaging (FLI), photoacoustic imaging (PAI), and photothermal imaging (PTI) to guide deep-tissue photonic hyperthermia, achieving precise removal and inhibition of breast cancer. Furthermore, combined with α-PD-1, ICR-QuNPs show huge potential to be a facile and efficient tool for photo-immunotherapy. More importantly, this study not only reports an "all-in-one" polymethine-based phototheranostic agent, but also sheds light on the exploration of versatile organic molecules for future practical applications.Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging ability and photothermal conversion efficiency (PCE) of phototheranostic agents. Hence, how to balance the competitive radiative and nonradiative processes of phototheranostic agents is the key factor to evaluate the phototheranostic effect. Herein, molecules named ICRs with high photostaibility are rationally designed, exhibiting fluorescence emission in the second near-infrared window (NIR-II, 1000-1700 nm) and high PCE, which are related to the strong donor-acceptor (D-A) interaction and high reorganization energy Noteworthily, ICR-Qu with stronger D-A interaction and a large-sized conjugated unit encapsulated in nanoparticles exhibits high PCE (81.1%). In addition, ICR-QuNPs are used for fluorescence imaging (FLI), photoacoustic imaging (PAI), and photothermal imaging (PTI) to guide deep-tissue photonic hyperthermia, achieving precise removal and inhibition of breast cancer. Furthermore, combined with α-PD-1, ICR-QuNPs show huge potential to be a facile and efficient tool for photo-immunotherapy. More importantly, this study not only reports an "all-in-one" polymethine-based phototheranostic agent, but also sheds light on the exploration of versatile organic molecules for future practical applications. Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging ability and photothermal conversion efficiency (PCE) of phototheranostic agents. Hence, how to balance the competitive radiative and nonradiative processes of phototheranostic agents is the key factor to evaluate the phototheranostic effect. Herein, molecules named ICRs with high photostaibility are rationally designed, exhibiting fluorescence emission in the second near‐infrared window (NIR‐II, 1000–1700 nm) and high PCE, which are related to the strong donor–acceptor (D–A) interaction and high reorganization energy Noteworthily, ICR‐Qu with stronger D–A interaction and a large‐sized conjugated unit encapsulated in nanoparticles exhibits high PCE (81.1%). In addition, ICR‐QuNPs are used for fluorescence imaging (FLI), photoacoustic imaging (PAI), and photothermal imaging (PTI) to guide deep‐tissue photonic hyperthermia, achieving precise removal and inhibition of breast cancer. Furthermore, combined with α‐PD‐1, ICR‐QuNPs show huge potential to be a facile and efficient tool for photo‐immunotherapy. More importantly, this study not only reports an “all‐in‐one” polymethine‐based phototheranostic agent, but also sheds light on the exploration of versatile organic molecules for future practical applications. Polymethine dyes with second near‐infrared emission and photoacoustic imaging capability are synthesized by the electronic‐donor group regulation strategy, which demonstrates high photothermal conversion efficiency (PCE = 81.1%) as an antitumor stategy in vivo and in vitro under the multimodal imaging guidance; theoretical calculation reveals the structure regulation mechanism for the polymethine‐based phototheranostic agent to achieve an excellent PCE. Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the demands of precision medicine. The diagnosis information and therapeutic effect are directly determined by the fluorescence imaging ability and photothermal conversion efficiency (PCE) of phototheranostic agents. Hence, how to balance the competitive radiative and nonradiative processes of phototheranostic agents is the key factor to evaluate the phototheranostic effect. Herein, molecules named ICRs with high photostaibility are rationally designed, exhibiting fluorescence emission in the second near‐infrared window (NIR‐II, 1000–1700 nm) and high PCE, which are related to the strong donor–acceptor (D–A) interaction and high reorganization energy Noteworthily, ICR‐Qu with stronger D–A interaction and a large‐sized conjugated unit encapsulated in nanoparticles exhibits high PCE (81.1%). In addition, ICR‐QuNPs are used for fluorescence imaging (FLI), photoacoustic imaging (PAI), and photothermal imaging (PTI) to guide deep‐tissue photonic hyperthermia, achieving precise removal and inhibition of breast cancer. Furthermore, combined with α‐PD‐1, ICR‐QuNPs show huge potential to be a facile and efficient tool for photo‐immunotherapy. More importantly, this study not only reports an “all‐in‐one” polymethine‐based phototheranostic agent, but also sheds light on the exploration of versatile organic molecules for future practical applications.
Author	Li, Kun Ran, Xiao‐Yun Chen, Ping Zhang, Li‐Na Liu, Yan‐Hong Yu, Xiao‐Qi Zhang, Hong Liu, Yan‐Zhao Shi, Lei Chen, Xue
Author_xml	– sequence: 1 givenname: Xiao‐Yun surname: Ran fullname: Ran, Xiao‐Yun organization: Sichuan University – sequence: 2 givenname: Ping surname: Chen fullname: Chen, Ping organization: Sichuan University – sequence: 3 givenname: Yan‐Zhao surname: Liu fullname: Liu, Yan‐Zhao organization: Sichuan University – sequence: 4 givenname: Lei surname: Shi fullname: Shi, Lei organization: Sichuan University – sequence: 5 givenname: Xue surname: Chen fullname: Chen, Xue organization: Sichuan University – sequence: 6 givenname: Yan‐Hong surname: Liu fullname: Liu, Yan‐Hong organization: Sichuan University – sequence: 7 givenname: Hong surname: Zhang fullname: Zhang, Hong organization: Sichuan University – sequence: 8 givenname: Li‐Na surname: Zhang fullname: Zhang, Li‐Na organization: Sichuan University – sequence: 9 givenname: Kun orcidid: 0000-0002-8788-1036 surname: Li fullname: Li, Kun email: kli@scu.edu.cn organization: Sichuan University – sequence: 10 givenname: Xiao‐Qi surname: Yu fullname: Yu, Xiao‐Qi organization: Xihua University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36630669$$D View this record in MEDLINE/PubMed
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Snippet	Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis and therapeutic to...
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SubjectTerms	Breast Neoplasms Coloring Agents Diagnosis Emission Female Fluorescence Humans Hyperthermia Immunotherapy Infrared windows Materials science Medical imaging Nanoparticles Nanoparticles - therapeutic use Near infrared radiation Neoplasms - diagnostic imaging Neoplasms - therapy Organic chemistry photoacoustic imaging Photoacoustic Techniques - methods photodynamic therapy Phototherapy - methods Photothermal conversion photothermal therapy polymethine dyes second near‐infrared emission Theranostic Nanomedicine - methods
Title	Rational Design of Polymethine Dyes with NIR‐II Emission and High Photothermal Conversion Efficiency for Multimodal‐Imaging‐Guided Photo‐Immunotherapy
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