Cell‐Free Extracts from Human Fat Tissue with a Hyaluronan‐Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization

Treatment for spinal cord injuries (SCIs) is often ineffective because SCIs result in a loss of nerve tissue, glial scar formation, local ischemia and secondary inflammation. The current promising strategy for SCI is the combination of bioactive materials and cytokines. Bioactive materials support t...

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Vydáno v:	Small (Weinheim an der Bergstrasse, Germany) Ročník 18; číslo 17; s. e2107838 - n/a
Hlavní autoři:	Xu, Guang‐Yu, Xu, Shun, Zhang, Yu‐Xuan, Yu, Zi‐You, Zou, Fei, Ma, Xiao‐Sheng, Xia, Xin‐Lei, Zhang, Wen‐Jie, Jiang, Jian‐Yuan, Song, Jian
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Germany Wiley Subscription Services, Inc 01.04.2022
Témata:	Animals Biocompatibility Biological activity Biomedical materials Cell Extracts Cytokines Cytokines - metabolism fat extract Genotype & phenotype Humans Hyaluronic acid Hyaluronic Acid - pharmacology Hydrogels Inflammation - drug therapy Inflammation - metabolism Injury prevention M2 polarization Macrophages Mice Microglia Nanotechnology Polarization Spinal cord Spinal cord injuries Spinal Cord Injuries - drug therapy STAT6 STAT6 M2 polarization spinal cord injuries fat extract
ISSN:	1613-6810, 1613-6829, 1613-6829
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Abstract	Treatment for spinal cord injuries (SCIs) is often ineffective because SCIs result in a loss of nerve tissue, glial scar formation, local ischemia and secondary inflammation. The current promising strategy for SCI is the combination of bioactive materials and cytokines. Bioactive materials support the injured spinal cord, stabilize the morphology, and avoid excessive inflammatory responses. Fat extract (FE) is a cell‐free liquid component containing a variety of cytokines extracted from human fat tissue using mechanical methods. In this research, a biocompatible HAMC (hyaluronan and methylcellulose) loaded with FE is used to treat a model of spinal cord contusion in mice. The composite not only inhibits death of neuro‐ and vascular cells and leads to the preservation of neural and vascular structure, but also modulates the inflammatory phenotype of macrophages in the locally injured region. Specifically, FE promotes the polarization of macrophages from an inflammatory M1 phenotype to an anti‐inflammatory M2 phenotype. During the screening of the involved pathways, it is corroborated that activation of the STAT6/Arg‐1 signaling pathway is involved in macrophage M2 polarization. In summary, FE is a promising treatment for SCI, as it is easy to obtain, nonimmunogenic, and effective. Fat extract (FE) is a cell‐free liquid component containing a variety of cytokines extracted from human fat tissue using mechanical methods. In this research, a biocompatible HAMC (hyaluronan and methylcellulose) loaded with FE is used to treat a model of spinal cord contusion in mice, which demonstrate an impressing recovery.
AbstractList	Treatment for spinal cord injuries (SCIs) is often ineffective because SCIs result in a loss of nerve tissue, glial scar formation, local ischemia and secondary inflammation. The current promising strategy for SCI is the combination of bioactive materials and cytokines. Bioactive materials support the injured spinal cord, stabilize the morphology, and avoid excessive inflammatory responses. Fat extract (FE) is a cell‐free liquid component containing a variety of cytokines extracted from human fat tissue using mechanical methods. In this research, a biocompatible HAMC (hyaluronan and methylcellulose) loaded with FE is used to treat a model of spinal cord contusion in mice. The composite not only inhibits death of neuro‐ and vascular cells and leads to the preservation of neural and vascular structure, but also modulates the inflammatory phenotype of macrophages in the locally injured region. Specifically, FE promotes the polarization of macrophages from an inflammatory M1 phenotype to an anti‐inflammatory M2 phenotype. During the screening of the involved pathways, it is corroborated that activation of the STAT6/Arg‐1 signaling pathway is involved in macrophage M2 polarization. In summary, FE is a promising treatment for SCI, as it is easy to obtain, nonimmunogenic, and effective. Treatment for spinal cord injuries (SCIs) is often ineffective because SCIs result in a loss of nerve tissue, glial scar formation, local ischemia and secondary inflammation. The current promising strategy for SCI is the combination of bioactive materials and cytokines. Bioactive materials support the injured spinal cord, stabilize the morphology, and avoid excessive inflammatory responses. Fat extract (FE) is a cell-free liquid component containing a variety of cytokines extracted from human fat tissue using mechanical methods. In this research, a biocompatible HAMC (hyaluronan and methylcellulose) loaded with FE is used to treat a model of spinal cord contusion in mice. The composite not only inhibits death of neuro- and vascular cells and leads to the preservation of neural and vascular structure, but also modulates the inflammatory phenotype of macrophages in the locally injured region. Specifically, FE promotes the polarization of macrophages from an inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. During the screening of the involved pathways, it is corroborated that activation of the STAT6/Arg-1 signaling pathway is involved in macrophage M2 polarization. In summary, FE is a promising treatment for SCI, as it is easy to obtain, nonimmunogenic, and effective.Treatment for spinal cord injuries (SCIs) is often ineffective because SCIs result in a loss of nerve tissue, glial scar formation, local ischemia and secondary inflammation. The current promising strategy for SCI is the combination of bioactive materials and cytokines. Bioactive materials support the injured spinal cord, stabilize the morphology, and avoid excessive inflammatory responses. Fat extract (FE) is a cell-free liquid component containing a variety of cytokines extracted from human fat tissue using mechanical methods. In this research, a biocompatible HAMC (hyaluronan and methylcellulose) loaded with FE is used to treat a model of spinal cord contusion in mice. The composite not only inhibits death of neuro- and vascular cells and leads to the preservation of neural and vascular structure, but also modulates the inflammatory phenotype of macrophages in the locally injured region. Specifically, FE promotes the polarization of macrophages from an inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. During the screening of the involved pathways, it is corroborated that activation of the STAT6/Arg-1 signaling pathway is involved in macrophage M2 polarization. In summary, FE is a promising treatment for SCI, as it is easy to obtain, nonimmunogenic, and effective. Treatment for spinal cord injuries (SCIs) is often ineffective because SCIs result in a loss of nerve tissue, glial scar formation, local ischemia and secondary inflammation. The current promising strategy for SCI is the combination of bioactive materials and cytokines. Bioactive materials support the injured spinal cord, stabilize the morphology, and avoid excessive inflammatory responses. Fat extract (FE) is a cell‐free liquid component containing a variety of cytokines extracted from human fat tissue using mechanical methods. In this research, a biocompatible HAMC (hyaluronan and methylcellulose) loaded with FE is used to treat a model of spinal cord contusion in mice. The composite not only inhibits death of neuro‐ and vascular cells and leads to the preservation of neural and vascular structure, but also modulates the inflammatory phenotype of macrophages in the locally injured region. Specifically, FE promotes the polarization of macrophages from an inflammatory M1 phenotype to an anti‐inflammatory M2 phenotype. During the screening of the involved pathways, it is corroborated that activation of the STAT6/Arg‐1 signaling pathway is involved in macrophage M2 polarization. In summary, FE is a promising treatment for SCI, as it is easy to obtain, nonimmunogenic, and effective. Fat extract (FE) is a cell‐free liquid component containing a variety of cytokines extracted from human fat tissue using mechanical methods. In this research, a biocompatible HAMC (hyaluronan and methylcellulose) loaded with FE is used to treat a model of spinal cord contusion in mice, which demonstrate an impressing recovery.
Author	Xu, Shun Zhang, Wen‐Jie Ma, Xiao‐Sheng Zhang, Yu‐Xuan Yu, Zi‐You Zou, Fei Xia, Xin‐Lei Jiang, Jian‐Yuan Xu, Guang‐Yu Song, Jian
Author_xml	– sequence: 1 givenname: Guang‐Yu surname: Xu fullname: Xu, Guang‐Yu organization: Fudan University – sequence: 2 givenname: Shun surname: Xu fullname: Xu, Shun organization: Fudan University – sequence: 3 givenname: Yu‐Xuan surname: Zhang fullname: Zhang, Yu‐Xuan organization: Fudan University – sequence: 4 givenname: Zi‐You surname: Yu fullname: Yu, Zi‐You organization: Shanghai Key Laboratory of Tissue Engineering – sequence: 5 givenname: Fei surname: Zou fullname: Zou, Fei organization: Fudan University – sequence: 6 givenname: Xiao‐Sheng surname: Ma fullname: Ma, Xiao‐Sheng organization: Fudan University – sequence: 7 givenname: Xin‐Lei surname: Xia fullname: Xia, Xin‐Lei organization: Fudan University – sequence: 8 givenname: Wen‐Jie surname: Zhang fullname: Zhang, Wen‐Jie organization: Shanghai Key Laboratory of Tissue Engineering – sequence: 9 givenname: Jian‐Yuan surname: Jiang fullname: Jiang, Jian‐Yuan email: jianyuanjiang@sina.com organization: Fudan University – sequence: 10 givenname: Jian orcidid: 0000-0001-5850-025X surname: Song fullname: Song, Jian email: jsong16@fudan.edu.cn organization: Fudan University
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Snippet	Treatment for spinal cord injuries (SCIs) is often ineffective because SCIs result in a loss of nerve tissue, glial scar formation, local ischemia and...
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SubjectTerms	Animals Biocompatibility Biological activity Biomedical materials Cell Extracts Cytokines Cytokines - metabolism fat extract Genotype & phenotype Humans Hyaluronic acid Hyaluronic Acid - pharmacology Hydrogels Inflammation - drug therapy Inflammation - metabolism Injury prevention M2 polarization Macrophages Mice Microglia Nanotechnology Polarization Spinal cord Spinal cord injuries Spinal Cord Injuries - drug therapy STAT6
Title	Cell‐Free Extracts from Human Fat Tissue with a Hyaluronan‐Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization
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