Evaluating efficacy of a novel dentifrice in reducing probing depths in Stage I and II periodontitis maintenance patients: A randomized, double‐blind, positive controlled clinical trial
Background Compliance to periodontal maintenance therapy (PMT) is essential for long‐term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical...
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| Vydané v: | Journal of periodontology (1970) Ročník 92; číslo 9; s. 1286 - 1294 |
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| Hlavní autori: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
01.09.2021
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| ISSN: | 0022-3492, 1943-3670, 1943-3670 |
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| Abstract | Background
Compliance to periodontal maintenance therapy (PMT) is essential for long‐term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investigate the effect of a novel dental gel on probing depths (PD) and inflammation when used as a home care dentifrice in Stage I and II periodontitis patients.
Methods
This double‐blind clinical study randomized 65 subjects with Stage I and II periodontitis to the novel dental gel containing 2.6% EDTA, and a commercially available anti‐gingivitis dentifrice with 0.454% stannous fluoride. Primary endpoint was PD at 6 months for those sites with baseline PD ≥ 4 mm and secondary endpoints included whole mouth mean scores of modified gingival index (MGI), modified sulcus bleeding index (mSBI) and plaque index (PI). No SRP was performed at baseline.
Results
Subjects using the novel dentifrice showed significant PD reductions of 1.18 mm (from 4.27 mm at baseline to 3.09 mm at 6 months) compared to 0.93 mm (from 4.23 mm at baseline to 3.30 mm at 6 months) shown for those using the positive control dentifrice. Difference between treatments at 6 months was 0.21 mm with P‐value = 0.0126. Significant improvements in MGI (P = 0.0000), mSBI (P = 0.0000), and PI (P = 0.0102) were also observed in 6 months.
Conclusion
The novel dentifrice showed significant reductions in PD and gingival inflammation over 6 months solely as a home care dentifrice without baseline SRP in Stage I and II periodontitis maintenance patients. |
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| AbstractList | Background
Compliance to periodontal maintenance therapy (PMT) is essential for long‐term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investigate the effect of a novel dental gel on probing depths (PD) and inflammation when used as a home care dentifrice in Stage I and II periodontitis patients.
Methods
This double‐blind clinical study randomized 65 subjects with Stage I and II periodontitis to the novel dental gel containing 2.6% EDTA, and a commercially available anti‐gingivitis dentifrice with 0.454% stannous fluoride. Primary endpoint was PD at 6 months for those sites with baseline PD ≥ 4 mm and secondary endpoints included whole mouth mean scores of modified gingival index (MGI), modified sulcus bleeding index (mSBI) and plaque index (PI). No SRP was performed at baseline.
Results
Subjects using the novel dentifrice showed significant PD reductions of 1.18 mm (from 4.27 mm at baseline to 3.09 mm at 6 months) compared to 0.93 mm (from 4.23 mm at baseline to 3.30 mm at 6 months) shown for those using the positive control dentifrice. Difference between treatments at 6 months was 0.21 mm with P‐value = 0.0126. Significant improvements in MGI (P = 0.0000), mSBI (P = 0.0000), and PI (P = 0.0102) were also observed in 6 months.
Conclusion
The novel dentifrice showed significant reductions in PD and gingival inflammation over 6 months solely as a home care dentifrice without baseline SRP in Stage I and II periodontitis maintenance patients. Compliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investigate the effect of a novel dental gel on probing depths (PD) and inflammation when used as a home care dentifrice in Stage I and II periodontitis patients. This double-blind clinical study randomized 65 subjects with Stage I and II periodontitis to the novel dental gel containing 2.6% EDTA, and a commercially available anti-gingivitis dentifrice with 0.454% stannous fluoride. Primary endpoint was PD at 6 months for those sites with baseline PD ≥ 4 mm and secondary endpoints included whole mouth mean scores of modified gingival index (MGI), modified sulcus bleeding index (mSBI) and plaque index (PI). No SRP was performed at baseline. Subjects using the novel dentifrice showed significant PD reductions of 1.18 mm (from 4.27 mm at baseline to 3.09 mm at 6 months) compared to 0.93 mm (from 4.23 mm at baseline to 3.30 mm at 6 months) shown for those using the positive control dentifrice. Difference between treatments at 6 months was 0.21 mm with P-value = 0.0126. Significant improvements in MGI (P = 0.0000), mSBI (P = 0.0000), and PI (P = 0.0102) were also observed in 6 months. The novel dentifrice showed significant reductions in PD and gingival inflammation over 6 months solely as a home care dentifrice without baseline SRP in Stage I and II periodontitis maintenance patients. Compliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investigate the effect of a novel dental gel on probing depths (PD) and inflammation when used as a home care dentifrice in Stage I and II periodontitis patients.BACKGROUNDCompliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investigate the effect of a novel dental gel on probing depths (PD) and inflammation when used as a home care dentifrice in Stage I and II periodontitis patients.This double-blind clinical study randomized 65 subjects with Stage I and II periodontitis to the novel dental gel containing 2.6% EDTA, and a commercially available anti-gingivitis dentifrice with 0.454% stannous fluoride. Primary endpoint was PD at 6 months for those sites with baseline PD ≥ 4 mm and secondary endpoints included whole mouth mean scores of modified gingival index (MGI), modified sulcus bleeding index (mSBI) and plaque index (PI). No SRP was performed at baseline.METHODSThis double-blind clinical study randomized 65 subjects with Stage I and II periodontitis to the novel dental gel containing 2.6% EDTA, and a commercially available anti-gingivitis dentifrice with 0.454% stannous fluoride. Primary endpoint was PD at 6 months for those sites with baseline PD ≥ 4 mm and secondary endpoints included whole mouth mean scores of modified gingival index (MGI), modified sulcus bleeding index (mSBI) and plaque index (PI). No SRP was performed at baseline.Subjects using the novel dentifrice showed significant PD reductions of 1.18 mm (from 4.27 mm at baseline to 3.09 mm at 6 months) compared to 0.93 mm (from 4.23 mm at baseline to 3.30 mm at 6 months) shown for those using the positive control dentifrice. Difference between treatments at 6 months was 0.21 mm with P-value = 0.0126. Significant improvements in MGI (P = 0.0000), mSBI (P = 0.0000), and PI (P = 0.0102) were also observed in 6 months.RESULTSSubjects using the novel dentifrice showed significant PD reductions of 1.18 mm (from 4.27 mm at baseline to 3.09 mm at 6 months) compared to 0.93 mm (from 4.23 mm at baseline to 3.30 mm at 6 months) shown for those using the positive control dentifrice. Difference between treatments at 6 months was 0.21 mm with P-value = 0.0126. Significant improvements in MGI (P = 0.0000), mSBI (P = 0.0000), and PI (P = 0.0102) were also observed in 6 months.The novel dentifrice showed significant reductions in PD and gingival inflammation over 6 months solely as a home care dentifrice without baseline SRP in Stage I and II periodontitis maintenance patients.CONCLUSIONThe novel dentifrice showed significant reductions in PD and gingival inflammation over 6 months solely as a home care dentifrice without baseline SRP in Stage I and II periodontitis maintenance patients. |
| Author | Cobb, Charles M. Nguyen, Brian L. Lam, Tracie M. Kaur, Maninder Takesh, Thair Otomo‐Corgel, Joan Nguyen, Audrey Lin, Kairong Geurs, Nicolaas C. Lee, June H. Wilder‐Smith, Petra |
| Author_xml | – sequence: 1 givenname: Maninder surname: Kaur fullname: Kaur, Maninder email: maninder@uab.edu organization: University of Alabama at Birmingham – sequence: 2 givenname: Nicolaas C. surname: Geurs fullname: Geurs, Nicolaas C. organization: University of Alabama at Birmingham – sequence: 3 givenname: Charles M. surname: Cobb fullname: Cobb, Charles M. organization: University of Missouri‐Kansas City – sequence: 4 givenname: Joan surname: Otomo‐Corgel fullname: Otomo‐Corgel, Joan organization: University of California at Los Angles – sequence: 5 givenname: Thair surname: Takesh fullname: Takesh, Thair organization: Department of Dentistry, University of California at Irvine – sequence: 6 givenname: June H. surname: Lee fullname: Lee, June H. organization: Department of Dentistry, University of California at Irvine – sequence: 7 givenname: Tracie M. surname: Lam fullname: Lam, Tracie M. organization: Department of Dentistry, University of California at Irvine – sequence: 8 givenname: Kairong surname: Lin fullname: Lin, Kairong organization: Department of Dentistry, University of California at Irvine – sequence: 9 givenname: Audrey surname: Nguyen fullname: Nguyen, Audrey organization: Department of Dentistry, University of California at Irvine – sequence: 10 givenname: Brian L. surname: Nguyen fullname: Nguyen, Brian L. organization: Department of Dentistry, University of California at Irvine – sequence: 11 givenname: Petra surname: Wilder‐Smith fullname: Wilder‐Smith, Petra organization: Department of Dentistry, University of California at Irvine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33331040$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/j.1600-051X.2004.00639.x 10.1007/s10654-016-0170-6 10.1111/j.1600-051X.1981.tb02039.x 10.1902/jop.2001.72.11.1535 10.1111/j.1600-051x.2004.00478.x 10.14219/jada.archive.2006.0110 10.1902/jop.1998.69.9.989 10.1001/jama.2013.281053 10.1016/j.adaj.2015.01.026 10.1111/jcpe.12368 10.1016/j.dsx.2019.03.023 10.1902/jop.1970.41.1.41 10.1136/bmj.321.7252.36 10.1002/lsm.22265 10.1902/jop.1996.67.6.555 10.4172/2161-1122.1000397 10.1016/j.adaj.2018.04.023 10.1111/jcpe.13245 10.1902/jop.2004.75.12.1592 10.1111/j.1600-051X.1979.tb01935.x 10.11607/prd.2656 10.1111/j.1600-051X.2005.00795.x 10.1002/JPER.17-0721 10.1902/annals.1999.4.1.1 10.1016/j.jds.2019.08.008 10.1002/JPER.17-0719 10.1111/jcpe.12945 10.1159/000327250 10.3390/dj7020056 10.3389/fnagi.2017.00336 10.1111/j.1600-0757.1994.tb00020.x 10.1111/idj.12305 |
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| Copyright | 2020 American Academy of Periodontology 2020 American Academy of Periodontology. |
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| Keywords | toothbrushing oral hygiene anti-inflammatory agents plaque control periodontitis |
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Compliance to periodontal maintenance therapy (PMT) is essential for long‐term periodontal health. Between PMT visits, patients must maintain good... Compliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral... |
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| SubjectTerms | anti‐inflammatory agents Dental Plaque Index Dentifrices - therapeutic use Double-Blind Method Gingivitis Humans oral hygiene periodontitis Periodontitis - drug therapy Periodontitis - prevention & control plaque control Tin Fluorides toothbrushing |
| Title | Evaluating efficacy of a novel dentifrice in reducing probing depths in Stage I and II periodontitis maintenance patients: A randomized, double‐blind, positive controlled clinical trial |
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