Development of Better Aptamers: Structured Library Approaches, Selection Methods, and Chemical Modifications

Systematic evolution of ligands by exponential enrichment (SELEX) has been used to discover thousands of aptamers since its development in 1990. Aptamers are short single‐stranded oligonucleotides capable of binding to targets with high specificity and selectivity through structural recognition. Whi...

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Veröffentlicht in:	Angewandte Chemie International Edition Jg. 63; H. 16; S. e202318665 - n/a
Hauptverfasser:	Brown, Alex, Brill, Jake, Amini, Ryan, Nurmi, Connor, Li, Yingfu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany Wiley Subscription Services, Inc 15.04.2024
Ausgabe:	International ed. in English
Schlagworte:	Aptamer Aptamers Aptamers, Nucleotide - chemistry Drug delivery Drug Delivery Systems Gene Library Immunogenicity In Vitro Selection Libraries Ligands Nucleic Acids Oligonucleotides Recognition SELEX SELEX Aptamer Technique - methods Structured Library Aptamer In Vitro Selection Structured Library Nucleic Acids SELEX
ISSN:	1433-7851, 1521-3773, 1521-3773
Online-Zugang:	Volltext
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