Synthesis of W‐Phos Ligand and Its Application in the Copper‐Catalyzed Enantioselective Addition of Linear Grignard Reagents to Ketones

The asymmetric catalytic addition of linear Grignard reagents to ketones has been a long‐standing challenge in organic synthesis. Herein, a novel family of PNP ligands (W‐Phos) was designed and applied in copper‐catalyzed asymmetric addition of linear Grignard reagents to aryl alkyl ketones, allowin...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 61; no. 29; pp. e202204443 - n/a
Main Authors:	Luo, Wenjun, Zhang, Li‐Ming, Zhang, Zhan‐Ming, Zhang, Junliang
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 18.07.2022 Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Alcohols Asymmetric Catalysis Asymmetry Chemistry Chemistry, Multidisciplinary Copper Enantiomers Grignard Reagents Ketones Ligands Physical Sciences Reagents Science & Technology Ketones Grignard Reagents ALKYLATION ASYMMETRIC ADDITION CHIRAL TERTIARY ALCOHOLS ALDEHYDES 1,2-ADDITION Alcohols ORGANOBORON REAGENTS ARYL ADDITIONS Asymmetric Catalysis CARBONYL DIALKYLZINC REAGENTS TITANIUM(IV) CATALYST Copper
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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