A Spiro Phosphamide Catalyzed Enantioselective Proton Transfer of Ylides in a Free Carbene Insertion into N−H Bonds

Free carbene readily causes multiple side reactions due to its high energy, thus its asymmetric transformation is very difficult. We present here our findings of high‐pKa Brønsted acid catalysts that enable free carbene insertion into N−H bonds of amines to prepare chiral α‐amino acid derivatives wi...

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Veröffentlicht in:	Angewandte Chemie International Edition Jg. 62; H. 15; S. e202300691 - n/a
Hauptverfasser:	Pan, Jia‐Bin, Zhang, Xuan‐Ge, Shi, Yi‐Fan, Han, Ai‐Cui, Chen, Yu‐Jia, Ouyang, Jing, Li, Mao‐Lin, Zhou, Qi‐Lin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	WEINHEIM Wiley 03.04.2023 Wiley Subscription Services, Inc
Ausgabe:	International ed. in English
Schlagworte:	Amines Amino acids Asymmetric Catalysis Brønsted Acids Carbenes Catalysts Chemistry Chemistry, Multidisciplinary Computer applications Enantiomers Insertion Intermediates Irradiation N−H Insertion Organic chemistry Phosphamides Physical Sciences Protons Science & Technology Side reactions Bronsted Acids PALLADIUM Asymmetric Catalysis ACIDITIES ACIDS N-H Insertion DIAZO-COMPOUNDS Phosphamides Carbenes Brønsted Acids N−H Insertion
ISSN:	1433-7851, 1521-3773, 1521-3773
Online-Zugang:	Volltext
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