GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health

In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during pr...

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Vydáno v:Current psychiatry reports Ročník 17; číslo 11; s. 92
Hlavní autoři: Bäckström, Torbjörn, Bixo, Marie, Strömberg, Jessica
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer US 01.11.2015
Springer Nature B.V
Témata:
Affect - drug effects
Affect - physiology
Female
GABA Modulators - metabolism
GABA Modulators - pharmacology
Humans
Medicine
Medicine & Public Health
Menstrual Cycle - drug effects
Menstrual Cycle - metabolism
Neurotransmitters
Pregnanolone - metabolism
Premenstrual Dysphoric Disorder - metabolism
Premenstrual Dysphoric Disorder - psychology
Premenstrual Dysphoric Disorder - therapy
Psychiatry
Receptors, GABA-A - metabolism
Section Editor
Steroids
Topical Collection on Women's Mental Health
Women's Mental Health (CN Epperson
GABA
Mood symptoms
receptor-modulating steroids
Premenstrual dysphoric disorder
GABAA receptor-modulating steroids
ISSN:1523-3812, 1535-1645, 1535-1645
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Shrnutí:In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during progesterone/allo treatment. Allo is a potent GABA A receptor-modulating steroid and as such is expected to be calming and anxiolytic. A relation to negative mood is unexpected. However, this paradoxical effect can be induced by all GABA A receptor modulators in low concentrations whereas higher concentrations are calming. The severity of the mood symptoms relate to allo in an inverted U-shaped curve at endogenous luteal-phase serum concentrations. Allo’s effects on the GABA A receptor can be antagonized by isoallopregnanolone (ISO), an antagonist to allo. ISO has also been used in a preliminary clinical trial on PMDD ameliorating symptoms with good effect in PMDD patients.
Bibliografie:ObjectType-Article-1
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ISSN:1523-3812
1535-1645
1535-1645
DOI:10.1007/s11920-015-0627-4