GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health

In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during pr...

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Vydáno v:	Current psychiatry reports Ročník 17; číslo 11; s. 92
Hlavní autoři:	Bäckström, Torbjörn, Bixo, Marie, Strömberg, Jessica
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.11.2015 Springer Nature B.V
Témata:	Affect - drug effects Affect - physiology Female GABA Modulators - metabolism GABA Modulators - pharmacology Humans Medicine Medicine & Public Health Menstrual Cycle - drug effects Menstrual Cycle - metabolism Neurotransmitters Pregnanolone - metabolism Premenstrual Dysphoric Disorder - metabolism Premenstrual Dysphoric Disorder - psychology Premenstrual Dysphoric Disorder - therapy Psychiatry Receptors, GABA-A - metabolism Section Editor Steroids Topical Collection on Women's Mental Health Women's Mental Health (CN Epperson GABA Mood symptoms receptor-modulating steroids Premenstrual dysphoric disorder GABAA receptor-modulating steroids
ISSN:	1523-3812, 1535-1645, 1535-1645
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Abstract	In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during progesterone/allo treatment. Allo is a potent GABA A receptor-modulating steroid and as such is expected to be calming and anxiolytic. A relation to negative mood is unexpected. However, this paradoxical effect can be induced by all GABA A receptor modulators in low concentrations whereas higher concentrations are calming. The severity of the mood symptoms relate to allo in an inverted U-shaped curve at endogenous luteal-phase serum concentrations. Allo’s effects on the GABA A receptor can be antagonized by isoallopregnanolone (ISO), an antagonist to allo. ISO has also been used in a preliminary clinical trial on PMDD ameliorating symptoms with good effect in PMDD patients.
AbstractList	In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during progesterone/allo treatment. Allo is a potent GABAA receptor-modulating steroid and as such is expected to be calming and anxiolytic. A relation to negative mood is unexpected. However, this paradoxical effect can be induced by all GABAA receptor modulators in low concentrations whereas higher concentrations are calming. The severity of the mood symptoms relate to allo in an inverted U-shaped curve at endogenous luteal-phase serum concentrations. Allo's effects on the GABAA receptor can be antagonized by isoallopregnanolone (ISO), an antagonist to allo. ISO has also been used in a preliminary clinical trial on PMDD ameliorating symptoms with good effect in PMDD patients.In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during progesterone/allo treatment. Allo is a potent GABAA receptor-modulating steroid and as such is expected to be calming and anxiolytic. A relation to negative mood is unexpected. However, this paradoxical effect can be induced by all GABAA receptor modulators in low concentrations whereas higher concentrations are calming. The severity of the mood symptoms relate to allo in an inverted U-shaped curve at endogenous luteal-phase serum concentrations. Allo's effects on the GABAA receptor can be antagonized by isoallopregnanolone (ISO), an antagonist to allo. ISO has also been used in a preliminary clinical trial on PMDD ameliorating symptoms with good effect in PMDD patients. In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during progesterone/allo treatment. Allo is a potent GABAA receptor-modulating steroid and as such is expected to be calming and anxiolytic. A relation to negative mood is unexpected. However, this paradoxical effect can be induced by all GABAA receptor modulators in low concentrations whereas higher concentrations are calming. The severity of the mood symptoms relate to allo in an inverted U-shaped curve at endogenous luteal-phase serum concentrations. Allo’s effects on the GABAA receptor can be antagonized by isoallopregnanolone (ISO), an antagonist to allo. ISO has also been used in a preliminary clinical trial on PMDD ameliorating symptoms with good effect in PMDD patients. In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during progesterone/allo treatment. Allo is a potent GABA A receptor-modulating steroid and as such is expected to be calming and anxiolytic. A relation to negative mood is unexpected. However, this paradoxical effect can be induced by all GABA A receptor modulators in low concentrations whereas higher concentrations are calming. The severity of the mood symptoms relate to allo in an inverted U-shaped curve at endogenous luteal-phase serum concentrations. Allo’s effects on the GABA A receptor can be antagonized by isoallopregnanolone (ISO), an antagonist to allo. ISO has also been used in a preliminary clinical trial on PMDD ameliorating symptoms with good effect in PMDD patients.
ArticleNumber	92
Author	Bixo, Marie Strömberg, Jessica Bäckström, Torbjörn
Author_xml	– sequence: 1 givenname: Torbjörn surname: Bäckström fullname: Bäckström, Torbjörn email: torbjorn.c.backstrom@umu.se organization: Department of Clinical sciences, Obstetrics and Gynecology, Umeå neurosteroid research center, Umeå University – sequence: 2 givenname: Marie surname: Bixo fullname: Bixo, Marie organization: Department of Clinical sciences, Obstetrics and Gynecology, Umeå neurosteroid research center, Umeå University – sequence: 3 givenname: Jessica surname: Strömberg fullname: Strömberg, Jessica organization: Department of Clinical sciences, Obstetrics and Gynecology, Umeå neurosteroid research center, Umeå University
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SubjectTerms	Affect - drug effects Affect - physiology Female GABA Modulators - metabolism GABA Modulators - pharmacology Humans Medicine Medicine & Public Health Menstrual Cycle - drug effects Menstrual Cycle - metabolism Neurotransmitters Pregnanolone - metabolism Premenstrual Dysphoric Disorder - metabolism Premenstrual Dysphoric Disorder - psychology Premenstrual Dysphoric Disorder - therapy Psychiatry Receptors, GABA-A - metabolism Section Editor Steroids Topical Collection on Women's Mental Health Women's Mental Health (CN Epperson
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Title	GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health
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