Exercise-based pre-habilitation is feasible and effective in radical cystectomy pathways—secondary results from a randomized controlled trial

Background Physical exercises offer a variety of health benefits to cancer survivors during and post-treatment. However, exercise-based pre-habilitation is not well reported in major uro-oncology surgery. The aim of this study was to investigate the feasibility, the adherence, and the efficacy of a...

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Vydané v:Supportive care in cancer Ročník 24; číslo 8; s. 3325 - 3331
Hlavní autori: Jensen, Bente Thoft, Laustsen, Sussie, Jensen, Jørgen Bjerggaard, Borre, Michael, Petersen, Annemette Krintel
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2016
Springer Nature B.V
Predmet:
Adherence
Aged
Bladder cancer
Body mass index
Body weight
Cancer
Cancer surgery
Clinical research
Clinical trials
Comorbidity
Cystectomy - rehabilitation
Efficacy
Exercise
Exercise - physiology
Exercise Therapy - methods
Feasibility
Female
Groups
Humans
Interdisciplinary aspects
Intervention
Length of stay
Male
Medical treatment
Medicine
Medicine & Public Health
Muscle strength
Muscular system
Nursing
Nursing Research
Nutrition
Oncology
Original Article
Pain Medicine
Patients
Perioperative care
Power
Prospective Studies
Rehabilitation
Rehabilitation Medicine
Short term
Surgery
Survivor
Training
Treatment Outcome
Treatment programs
Urogenital system
Adherence
Muscle power
Physical capacity
Pre-habilitation
Exercise-based intervention
Radical cystectomy
Recovery
ISSN:0941-4355, 1433-7339
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Shrnutí:Background Physical exercises offer a variety of health benefits to cancer survivors during and post-treatment. However, exercise-based pre-habilitation is not well reported in major uro-oncology surgery. The aim of this study was to investigate the feasibility, the adherence, and the efficacy of a short-term physical pre-habilitation program to patients with invasive bladder cancer awaiting radical cystectomy (RC). Methods A parent prospective randomized controlled clinical trial investigated efficacy of a multidisciplinary rehabilitation program on length of stay following RC. A total of 107 patients were included in the intension-to-treat population revealing 50 patients in the intervention group and 57 patients in the standard group. Pre-operatively, the intervention group was instructed to a standardized exercise program consisting of both muscle strength exercises and endurance training. The number of training sessions and exercise repetitions was patient-reported. Feasibility was expressed as adherence to the program and efficacy as the differences in muscle power within and between treatment groups at time for surgery. Results A total of 66 % (95 % confidence interval (CI) 51; 78) adhered more than 75 % of the recommended progressive standardized exercise program. In the intervention group, a significant improvement in muscle power of 18 % ( p  < 0.002) was found at time for surgery. Moreover, muscle power was significantly improved compared to that in the standard group with 0.3 W/kg (95 % CI 0.08; 0.5 %) ( p  < 0.006). Adherence was not associated with pre-operative BMI, nutritional risk, comorbidity, pain, gender, or age. Conclusion In patients awaiting RC, a short-term exercise-based pre-habilitation intervention is feasible and effective and should be considered in future survivorship strategies.
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ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-016-3140-3