The Effect of Glatiramer Acetate on Retinal Nerve Fiber Layer Thickness in Patients with Relapsing–Remitting Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study

Background Optical coherence tomography (OCT) is a technique that allows for the assessment of retinal nerve fiber layer thickness (RNFLT) and total macular volume (TMV), which reflect neuroaxonal integrity within the retina. As such it has been used in multiple sclerosis (MS) to study neurodegenera...

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Vydáno v:CNS drugs Ročník 32; číslo 8; s. 763 - 770
Hlavní autoři: Zivadinov, Robert, Tavazzi, Eleonora, Hagemeier, Jesper, Carl, Ellen, Hojnacki, David, Kolb, Channa, Weinstock-Guttman, Bianca
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.08.2018
Springer Nature B.V
Témata:
Adult
Atrophy
Case-Control Studies
Cohort Studies
Copolymer 1
Diabetic retinopathy
Eye
Female
Glatiramer Acetate - therapeutic use
Humans
Immunosuppressive Agents - therapeutic use
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - drug therapy
Multiple Sclerosis, Relapsing-Remitting - pathology
Nerve Fibers - drug effects
Nerve Fibers - pathology
Neuritis
Neurodegeneration
Neurology
Neuroprotection
Neurosciences
Optic neuritis
Optic Neuritis - drug therapy
Optic Neuritis - etiology
Optic Neuritis - pathology
Optics
Original Research Article
Pathology
Patients
Pharmacotherapy
Psychiatry
Psychopharmacology
Retina
Retina - pathology
Severity of Illness Index
Single-Blind Method
Studies
Systematic review
Tomography
Tomography, Optical Coherence
Treatment Outcome
ISSN:1172-7047, 1179-1934, 1179-1934
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Popis
Shrnutí:Background Optical coherence tomography (OCT) is a technique that allows for the assessment of retinal nerve fiber layer thickness (RNFLT) and total macular volume (TMV), which reflect neuroaxonal integrity within the retina. As such it has been used in multiple sclerosis (MS) to study neurodegeneration. Glatiramer acetate (GA) is a widely used treatment for MS, which is suggested to have a possible neuroprotective role. Objective The aim of this study was to assess RFNLT and TMV changes in relapsing–remitting MS (RRMS) patients who started treatment with GA and were followed for a 24-month period. Methods A cohort of 60 RRMS patients and 40 healthy controls (HCs) were imaged with OCT at baseline and follow-up. All subjects also underwent clinical and neurological examination. Measurements were compared between the RRMS patients and HCs as well as between optic neuritis (ON)-affected and ON-unaffected eyes. Results At baseline, MS patients showed lower average RNFLT ( p  = 0.046) and TMV ( p  = 0.013) when compared with HCs. No significant differences in the evolution of OCT measures were detected over the follow-up between MS patients and HCs. MS patients with both affected and unaffected eyes showed significantly lower average RNFLT, temporal inferior RNFLT, and TMV at baseline, compared with HCs. No significant differences between ON-affected and ON-unaffected eyes in MS patients were detected over the follow-up, except for the nasal superior RNFLT ( p  = 0.019). Conclusions This study suggests a beneficial role of GA on retinal axonal degeneration in MS, and further confirms the utility of OCT to monitor the neuroprotective effect of disease-modifying treatment.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1172-7047
1179-1934
1179-1934
DOI:10.1007/s40263-018-0521-9