Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies

Abnormal tumour vasculature has a significant impact on tumour progression and response to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis and, thus, can be delivered to normalize tumour vasculature. However, a NO-delivery system with a prolonged half-life and a...

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Bibliographic Details
Published in:	Nature nanotechnology Vol. 14; no. 12; pp. 1160 - 1169
Main Authors:	Sung, Yun-Chieh, Jin, Pei-Ru, Chu, Li-An, Hsu, Fu-Fei, Wang, Mei-Ren, Chang, Chih-Chun, Chiou, Show-Jen, Qiu, Jiantai Timothy, Gao, Dong-Yu, Lin, Chu-Chi, Chen, Yu-Sing, Hsu, Yi-Chiung, Wang, Jane, Wang, Fu-Nien, Yu, Pei-Lun, Chiang, Ann-Shyn, Wu, Anthony Yan-Tang, Ko, John Jun-Sheng, Lai, Charles Pin-Kuang, Lu, Tsai-Te, Chen, Yunching
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.12.2019
Subjects:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - therapeutic use Angiogenesis Animals Apoptosis Blood vessels Cancer Cancer therapies Cancer vaccines Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - drug therapy Controlled release Delayed-Action Preparations - chemistry Drug delivery systems Hepatocellular carcinoma Homeostasis Humans Immunostimulation Immunotherapy Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - drug therapy Male Metastases Mice Microenvironments Nanoparticles - chemistry Neovascularization, Pathologic - drug therapy Nitric oxide Nitric Oxide - administration & dosage Nitric Oxide - therapeutic use Phenotypes Sustained release Therapy Tumor microenvironment Tumor Microenvironment - drug effects Tumor necrosis factor Tumors
ISSN:	1748-3387, 1748-3395, 1748-3395
Online Access:	Get full text
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